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docs/index.html

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<link href="site_libs/quarto-html/quarto-syntax-highlighting-2f5df379a58b258e96c21c0638c20c03.css" rel="stylesheet" id="quarto-text-highlighting-styles">
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<script src="site_libs/bootstrap/bootstrap.min.js"></script>
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<link href="site_libs/bootstrap/bootstrap-icons.css" rel="stylesheet">
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<link href="site_libs/bootstrap/bootstrap-0ec6211309129a110f55943800a981fd.min.css" rel="stylesheet" append-hash="true" id="quarto-bootstrap" data-mode="light">
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<link href="site_libs/bootstrap/bootstrap-6e5bad59d9c561bd033d0b48217d8615.min.css" rel="stylesheet" append-hash="true" id="quarto-bootstrap" data-mode="light">
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<script src="site_libs/quarto-contrib/iconify-1.0.0-beta.2/iconify-icon.min.js"></script>
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<script id="quarto-search-options" type="application/json">{
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<li class="sidebar-item">
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<div class="sidebar-item-container">
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<a href="./pdb.html" class="sidebar-item-text sidebar-link">
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<span class="menu-text">Protein Structures</span></a>
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<span class="menu-text">Protein Structures Analysis</span></a>
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</div>
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</li>
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<li class="sidebar-item">
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<div class="sidebar-item-container">
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<a href="./structures.html" class="sidebar-item-text sidebar-link">
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<span class="menu-text">Parsing Protein Structures</span></a>
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<span class="menu-text">Ex.1: Parsing Protein Structures</span></a>
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</div>
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</li>
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</ul>
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<li class="sidebar-item">
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<div class="sidebar-item-container">
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<a href="./casp.html" class="sidebar-item-text sidebar-link">
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<span class="menu-text">UAM CASP competition</span></a>
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<span class="menu-text">Ex.2: UAM CASP competition</span></a>
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</div>
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</li>
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</figure>
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<p>This is a <a href="https://quarto.org/">Quarto</a> site containing the materials for the <em>Structural Bioinformatics</em> course in the <a href="https://www-uam-es.translate.goog/Medicina/MasterBioinformaticaBiologiaComputacional/1446820907497.htm?language=es&amp;nodepath=M?ster+Universitario+en+Bioinform?tica+y+Biolog?a+Computacional&amp;_x_tr_sl=es&amp;_x_tr_tl=en&amp;_x_tr_hl=es&amp;_x_tr_pto=wapp">Master’s Degree in Bioinformatics &amp; Computational Biology @UAM</a>. All these materials are open access and shared under <a href="https://creativecommons.org/licenses/by-nc/2.0/" title="CC BY-NC license">CC BY-NC license</a>. These materials were originally elaborated for the 2022 course edition and is subsequently revised each year. The current Course syllabus for year 2025-2026 can be found <a href="2025_33082_es.pdf">here</a> (in Spanish). Detailed academic information about the course contents, dates and assessment only can be found at the UAM <a href="https://posgrado.uam.es/">Moodle</a> site.</p>
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<p>This is a <a href="https://quarto.org/">Quarto</a> site containing the materials for the <em>Structural Bioinformatics</em> course in the <a href="https://www.uam.es/medicina/masterbioinfo">Master’s Degree in Bioinformatics &amp; Computational Biology @UAM</a>. All these materials are open access and shared under <a href="https://creativecommons.org/licenses/by-nc/2.0/" title="CC BY-NC license">CC BY-NC license</a>. These materials were originally elaborated for the 2022 course edition and is subsequently revised each year. The current Course syllabus for year 2025-2026 can be found <a href="2025_33082_es.pdf">here</a> (in Spanish). Detailed academic information about the course contents, dates and assessment only can be found at the UAM <a href="https://posgrado.uam.es/">Moodle</a> site.</p>
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<div class="callout callout-style-default callout-note callout-titled">
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docs/intro.html

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<strong>How many unique protein chains are there is this protein?</strong>
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<label><input type="radio" autocomplete="off" name="radio_XQXZAGMKQV" value=""> <span>1</span></label><label><input type="radio" autocomplete="off" name="radio_XQXZAGMKQV" value="answer"> <span>2</span></label><label><input type="radio" autocomplete="off" name="radio_XQXZAGMKQV" value=""> <span>3</span></label><label><input type="radio" autocomplete="off" name="radio_XQXZAGMKQV" value=""> <span>&gt;3</span></label>
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<div id="radio_CMVVNTZDOS" class="webex-radiogroup">
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<label><input type="radio" autocomplete="off" name="radio_CMVVNTZDOS" value=""> <span>1</span></label><label><input type="radio" autocomplete="off" name="radio_CMVVNTZDOS" value="answer"> <span>2</span></label><label><input type="radio" autocomplete="off" name="radio_CMVVNTZDOS" value=""> <span>3</span></label><label><input type="radio" autocomplete="off" name="radio_CMVVNTZDOS" value=""> <span>&gt;3</span></label>
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<strong>Which structural class is the protein above?</strong>
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<label><input type="radio" autocomplete="off" name="radio_PHEAWYARGO" value=""> <span>All-α</span></label><label><input type="radio" autocomplete="off" name="radio_PHEAWYARGO" value=""> <span>All β</span></label><label><input type="radio" autocomplete="off" name="radio_PHEAWYARGO" value="answer"> <span>α/β</span></label><label><input type="radio" autocomplete="off" name="radio_PHEAWYARGO" value=""> <span>α+β</span></label><label><input type="radio" autocomplete="off" name="radio_PHEAWYARGO" value=""> <span>Small</span></label>
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<div id="radio_XHTQWEZIGH" class="webex-radiogroup">
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<label><input type="radio" autocomplete="off" name="radio_XHTQWEZIGH" value=""> <span>All-α</span></label><label><input type="radio" autocomplete="off" name="radio_XHTQWEZIGH" value=""> <span>All β</span></label><label><input type="radio" autocomplete="off" name="radio_XHTQWEZIGH" value="answer"> <span>α/β</span></label><label><input type="radio" autocomplete="off" name="radio_XHTQWEZIGH" value=""> <span>α+β</span></label><label><input type="radio" autocomplete="off" name="radio_XHTQWEZIGH" value=""> <span>Small</span></label>
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<p>As you can see, as the protein is larger, classification gets more difficult. Moreover, as fold space has become more and more complex, these types of classifications have been adjusted and extended such that a complete hierarchy is created. The most commonly referred approaches to this sort of classification are those used by SCOP and CATH databases, as we will see in the <a href="ddbb.html#strDDBB">Structural Databases</a> section.</p>
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index.qmd

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---
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![](pics/QR_master.png "Master's Degree in Bioinformatics & Computational Biology"){fig-align="right"}
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This is a [Quarto](https://quarto.org/) site containing the materials for the *Structural Bioinformatics* course in the [Master's Degree in Bioinformatics & Computational Biology \@UAM](https://www-uam-es.translate.goog/Medicina/MasterBioinformaticaBiologiaComputacional/1446820907497.htm?language=es&nodepath=M?ster+Universitario+en+Bioinform?tica+y+Biolog?a+Computacional&_x_tr_sl=es&_x_tr_tl=en&_x_tr_hl=es&_x_tr_pto=wapp). All these materials are open access and shared under [CC BY-NC license](https://creativecommons.org/licenses/by-nc/2.0/ "CC BY-NC license"). These materials were originally elaborated for the 2022 course edition and is subsequently revised each year. The current Course syllabus for year 2025-2026 can be found [here](2025_33082_es.pdf) (in Spanish). Detailed academic information about the course contents, dates and assessment only can be found at the UAM [Moodle](https://posgrado.uam.es/) site.
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This is a [Quarto](https://quarto.org/) site containing the materials for the *Structural Bioinformatics* course in the [Master's Degree in Bioinformatics & Computational Biology \@UAM](https://www.uam.es/medicina/masterbioinfo). All these materials are open access and shared under [CC BY-NC license](https://creativecommons.org/licenses/by-nc/2.0/ "CC BY-NC license"). These materials were originally elaborated for the 2022 course edition and is subsequently revised each year. The current Course syllabus for year 2025-2026 can be found [here](2025_33082_es.pdf) (in Spanish). Detailed academic information about the course contents, dates and assessment only can be found at the UAM [Moodle](https://posgrado.uam.es/) site.
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::: callout-note
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This is primarily an introductory course (3 ECTS), designed to offer a general overview as well as tools and resources necessary for initiating SB research projects. Consequently, many fundamental concepts in protein biophysics, scripting tools for SB, and deep-learning methods will only be briefly covered.

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