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AUC estimation streamline conc scale for estimation - add argument #60

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sedavid01 opened this issue Oct 10, 2023 · 0 comments · Fixed by #64
Open
4 tasks done

AUC estimation streamline conc scale for estimation - add argument #60

sedavid01 opened this issue Oct 10, 2023 · 0 comments · Fixed by #64
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documentation Improvements or additions to documentation enhancement New feature or request

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sedavid01 commented Oct 10, 2023

Referring back to previous conversations with SME's that utilize AUC for their summary statistics of dose-response models, AUC values for all models should be estimated on the same concentration scale.

Goal: Add functionality to AUC calculation functions that allows a user to determine whether the AUC should be estimated with the concentration on the raw or log-scale, and will estimate AUC's on a consistent scale with consistent interpretation across fits.

Needs:

  • Add a new argument to the AUC functions allowing indication of log-scale concentration used for estimating the AUC value.
  • Add functions without a log-scale re-parameterization that will be needed for the consistent AUC estimation on the log-scale.
  • Update internal logic for get_AUC to accommodate for the new argument/logic flow of the function.
  • Update documentation for the respective R functions.

Nice to have's:

  • Message or warning regarding which scale the AUC is estimated in.
  • Optional output providing "meta-data" on which concentration-scale is used for AUC estimation.
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