Atomic Operations Extension (json-api/json-api#1437) and the somewhat related Local Identities Extention : json-api/json-api#1436) are the two cornerstones of the path taken by JSON:API spec to support multiple operations in HTTP one request.
The work done in #282 can hopefully be reused and adapted. I'm gonna work on it once I have a working server-side implementation for Drupal.