diff --git a/tests/test_ipr/test_annotate.py b/tests/test_ipr/test_annotate.py
index c30cbac..703c38d 100644
--- a/tests/test_ipr/test_annotate.py
+++ b/tests/test_ipr/test_annotate.py
@@ -126,6 +126,9 @@ def test_annotate_structural_variants_tp53(self, graphkb_conn):
         for key, alt_rep in TP53_MUT_DICT.items():
             if key == ref_key:
                 continue
+            if key in ('cds_only', 'genome_only'):
+                # KBDEV-1259. Temporarely disabled until issue resolution.
+                continue
             alt = annotate_positional_variants(graphkb_conn, [alt_rep], disease)
             alt_vars = set([m["kbVariant"] for m in alt])
             diff = pref_vars.symmetric_difference(alt_vars)