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Also, something to consider, we can do object stream of like { name, seq, name2, quality }, or somehow do it in a way that lets the seq and quality themselves be streamed. Else you need to store the entire seq and quality in memory (in the object) which somewhat defeats the purpose of streaming.
I have made some changes to accomplish this but still experimental. Checkout branch Refactoring. Also, added a sample file with some possible problems while parsing fastq (check it here). Now, it handles empty lines, both with spaces and no spaces and can at the same time handle "@" character in quality recognizing properly the name. Please test it and see what you think (just run ./lib/bionode-fastq.js, since it has a test here).
Refactor to use through2, split2, pumpify.
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