diff --git a/.changeset/social-items-strive.md b/.changeset/social-items-strive.md
new file mode 100644
index 00000000000..202bbd3f2e0
--- /dev/null
+++ b/.changeset/social-items-strive.md
@@ -0,0 +1,5 @@
+---
+'@clerk/ui': patch
+---
+
+Fix role select being disabled on `OrganizationProfile` invite members page when default role is not in roles list
diff --git a/packages/ui/src/components/OrganizationProfile/InviteMembersForm.tsx b/packages/ui/src/components/OrganizationProfile/InviteMembersForm.tsx
index 7f9e848850b..3a8ecc68b8d 100644
--- a/packages/ui/src/components/OrganizationProfile/InviteMembersForm.tsx
+++ b/packages/ui/src/components/OrganizationProfile/InviteMembersForm.tsx
@@ -48,19 +48,10 @@ export const InviteMembersForm = (props: InviteMembersFormProps) => {
     label: localizationKeys('formFieldLabel__emailAddresses'),
   });
 
-  const defaultRole = useDefaultRole();
   const roleField = useFormControl('role', '', {
     label: localizationKeys('formFieldLabel__role'),
   });
 
-  useEffect(() => {
-    if (roleField.value || !defaultRole) {
-      return;
-    }
-
-    roleField.setValue(defaultRole);
-  }, [defaultRole, roleField]);
-
   if (!organization) {
     return null;
   }
@@ -200,8 +191,23 @@ export const InviteMembersForm = (props: InviteMembersFormProps) => {
 
 const AsyncRoleSelect = (field: ReturnType<typeof useFormControl<'role'>>) => {
   const { options, isLoading, hasRoleSetMigration } = useFetchRoles();
-
   const { t } = useLocalizations();
+  const defaultRole = useDefaultRole();
+
+  useEffect(() => {
+    if (field.value || !defaultRole) {
+      return;
+    }
+
+    // Skip if the default role from org settings is not in the current role set
+    // This will eventually be returned by the roles endpoint, and `organizationSettings.domains.defaultRole` will be deprecated
+    const defaultRoleExists = options?.some(option => option.value === defaultRole);
+    if (!defaultRoleExists) {
+      return;
+    }
+
+    field.setValue(defaultRole);
+  }, [defaultRole, options, field]);
 
   return (
     <Form.ControlRow elementId={field.id}>
diff --git a/packages/ui/src/components/OrganizationProfile/__tests__/InviteMembersPage.test.tsx b/packages/ui/src/components/OrganizationProfile/__tests__/InviteMembersPage.test.tsx
index c6dede1606d..2eaf39d7aa3 100644
--- a/packages/ui/src/components/OrganizationProfile/__tests__/InviteMembersPage.test.tsx
+++ b/packages/ui/src/components/OrganizationProfile/__tests__/InviteMembersPage.test.tsx
@@ -1,7 +1,6 @@
 import { ClerkAPIResponseError } from '@clerk/shared/error';
 import type { OrganizationInvitationResource } from '@clerk/shared/types';
 import { waitFor } from '@testing-library/react';
-import React from 'react';
 import { beforeEach, describe, expect, it, vi } from 'vitest';
 
 import { bindCreateFixtures } from '@/test/create-fixtures';
@@ -246,6 +245,59 @@ describe('InviteMembersPage', () => {
       await waitFor(() => expect(getByRole('button', { name: /select role/i })).toBeInTheDocument());
     });
 
+    it('enables selecting other options if default role is not available', async () => {
+      const { wrapper, fixtures } = await createFixtures(f => {
+        f.withOrganizations();
+        f.withOrganizationDomains(undefined, 'mydefaultrole');
+        f.withUser({
+          email_addresses: ['test@clerk.com'],
+          organization_memberships: [{ name: 'Org1', role: 'admin' }],
+        });
+      });
+
+      fixtures.clerk.organization?.getInvitations.mockRejectedValue(null);
+      fixtures.clerk.organization?.getRoles.mockResolvedValue({
+        total_count: 1,
+        data: [
+          {
+            pathRoot: '',
+            reload: vi.fn(),
+            id: 'member',
+            key: 'member',
+            name: 'member',
+            description: '',
+            permissions: [],
+            createdAt: new Date(),
+            updatedAt: new Date(),
+          },
+          {
+            pathRoot: '',
+            reload: vi.fn(),
+            id: 'admin',
+            key: 'admin',
+            name: 'admin',
+            description: '',
+            permissions: [],
+            createdAt: new Date(),
+            updatedAt: new Date(),
+          },
+        ],
+      });
+
+      fixtures.clerk.organization?.inviteMembers.mockResolvedValueOnce([{}] as OrganizationInvitationResource[]);
+      const { getByRole, userEvent, getByTestId } = render(
+        <Action.Root>
+          <InviteMembersScreen />
+        </Action.Root>,
+        { wrapper },
+      );
+      await userEvent.type(getByTestId('tag-input'), 'test+1@clerk.com,');
+      await waitFor(() => expect(getByRole('button', { name: /select role/i })).toBeInTheDocument());
+      await userEvent.click(getByRole('button', { name: /select role/i }));
+      await userEvent.click(getByRole('button', { name: /admin/i }));
+      await waitFor(() => expect(getByRole('button', { name: 'Send invitations' })).not.toBeDisabled());
+    });
+
     it('enables send button with default role once email address has been entered', async () => {
       const defaultRole = 'mydefaultrole';