diff --git a/deepmd/utils/finetune.py b/deepmd/utils/finetune.py
index 5dd3623cba..8d4b728af4 100644
--- a/deepmd/utils/finetune.py
+++ b/deepmd/utils/finetune.py
@@ -19,7 +19,7 @@
 
 log = logging.getLogger(__name__)
 
-_IGNORED_DESCRIPTOR_KEYS = frozenset({"trainable"})
+_IGNORED_DESCRIPTOR_KEYS = frozenset({"trainable", "seed", "use_amp"})
 _MISSING = object()
 _MAX_DESCRIPTOR_CONFIG_DIFFS = 20
 _MAX_CONFIG_VALUE_LENGTH = 200
diff --git a/source/tests/common/test_finetune_utils.py b/source/tests/common/test_finetune_utils.py
index 33547b34d0..ed51ba6651 100644
--- a/source/tests/common/test_finetune_utils.py
+++ b/source/tests/common/test_finetune_utils.py
@@ -87,6 +87,28 @@ def test_descriptor_config_warning_skips_default_only_difference(caplog):
     assert caplog.text == ""
 
 
+def test_descriptor_config_warning_skips_runtime_only_differences(monkeypatch, caplog):
+    monkeypatch.setattr(
+        finetune,
+        "_normalize_descriptor_for_compare",
+        lambda descriptor: descriptor,
+    )
+
+    runtime_only_differences = [
+        ({"type": "se_e2_a", "seed": None}, {"type": "se_e2_a", "seed": 42}),
+        ({"type": "dpa4c", "use_amp": False}, {"type": "dpa4c", "use_amp": True}),
+    ]
+    for input_descriptor, pretrained_descriptor in runtime_only_differences:
+        caplog.clear()
+        with caplog.at_level(logging.WARNING):
+            finetune.warn_configuration_mismatch_during_finetune(
+                input_descriptor,
+                pretrained_descriptor,
+            )
+
+        assert caplog.text == ""
+
+
 def test_descriptor_config_warning_falls_back_to_raw_if_normalization_fails(
     monkeypatch, caplog
 ):