diff --git a/src/obspec_utils/stores/_aiohttp.py b/src/obspec_utils/stores/_aiohttp.py
index 1f19432..fcb9986 100644
--- a/src/obspec_utils/stores/_aiohttp.py
+++ b/src/obspec_utils/stores/_aiohttp.py
@@ -26,10 +26,11 @@
 from __future__ import annotations
 
 import asyncio
-from collections.abc import AsyncIterator, Iterator, Sequence
+import threading
+from collections.abc import AsyncIterator, Coroutine, Iterator, Sequence
 from dataclasses import dataclass, field
 from datetime import datetime, timezone
-from typing import TYPE_CHECKING
+from typing import TYPE_CHECKING, TypeVar
 
 from obspec import GetResult, GetResultAsync
 
@@ -38,6 +39,8 @@
 if TYPE_CHECKING:
     from obspec import Attributes, GetOptions, ObjectMeta
 
+T = TypeVar("T")
+
 try:
     import aiohttp
 except ImportError as e:
@@ -196,6 +199,10 @@ def __init__(
         self.headers = headers or {}
         self.timeout = aiohttp.ClientTimeout(total=timeout)
         self._session: aiohttp.ClientSession | None = None
+        # Event loop for sync methods when called from async context (e.g., Jupyter)
+        self._sync_loop: asyncio.AbstractEventLoop | None = None
+        self._sync_thread: threading.Thread | None = None
+        self._sync_lock = threading.Lock()
 
     async def __aenter__(self) -> "AiohttpStore":
         """Enter the async context manager, creating a reusable session."""
@@ -211,6 +218,52 @@ async def __aexit__(self, exc_type, exc_val, exc_tb) -> None:
             await self._session.close()
             self._session = None
 
+    def _get_sync_loop(self) -> asyncio.AbstractEventLoop:
+        """Get or create event loop for sync operations when inside a running loop."""
+        if self._sync_loop is None:
+            with self._sync_lock:
+                if self._sync_loop is None:
+                    loop = asyncio.new_event_loop()
+                    thread = threading.Thread(
+                        target=loop.run_forever,
+                        name=f"aiohttp_store_{id(self)}",
+                        daemon=True,
+                    )
+                    thread.start()
+                    self._sync_loop = loop
+                    self._sync_thread = thread
+        return self._sync_loop
+
+    def _run_sync(self, coro: Coroutine[None, None, T]) -> T:
+        """Run coroutine synchronously, handling nested event loops (e.g., Jupyter)."""
+        try:
+            asyncio.get_running_loop()
+        except RuntimeError:
+            # No running loop - use asyncio.run() directly
+            return asyncio.run(coro)
+
+        # Inside running loop - use store's dedicated loop
+        loop = self._get_sync_loop()
+        future = asyncio.run_coroutine_threadsafe(coro, loop)
+        return future.result()
+
+    def _cleanup_sync_loop(self) -> None:
+        """Stop the sync loop and thread."""
+        if self._sync_loop is not None:
+            self._sync_loop.call_soon_threadsafe(self._sync_loop.stop)
+            if self._sync_thread is not None:
+                self._sync_thread.join(timeout=1.0)
+            self._sync_loop = None
+            self._sync_thread = None
+
+    def close(self) -> None:
+        """Close the store and release resources."""
+        self._cleanup_sync_loop()
+
+    def __del__(self) -> None:
+        """Clean up on garbage collection."""
+        self._cleanup_sync_loop()
+
     def _build_url(self, path: str) -> str:
         """Build the full URL from base URL and path."""
         path = path.removeprefix("/")
@@ -497,7 +550,7 @@ def get(
         AiohttpGetResult
             Result object with buffer() method and metadata.
         """
-        result = asyncio.run(self.get_async(path, options=options))
+        result = self._run_sync(self.get_async(path, options=options))
         return AiohttpGetResult(
             _data=result._data,
             _meta=result._meta,
@@ -534,7 +587,7 @@ def get_range(
         bytes
             The requested byte range.
         """
-        return asyncio.run(
+        return self._run_sync(
             self.get_range_async(path, start=start, end=end, length=length)
         )
 
@@ -567,7 +620,7 @@ def get_ranges(
         Sequence[bytes]
             The requested byte ranges.
         """
-        return asyncio.run(
+        return self._run_sync(
             self.get_ranges_async(path, starts=starts, ends=ends, lengths=lengths)
         )
 
@@ -627,7 +680,7 @@ def head(self, path: str) -> ObjectMeta:
         ObjectMeta
             File metadata including size, last_modified, e_tag, etc.
         """
-        return asyncio.run(self.head_async(path))
+        return self._run_sync(self.head_async(path))
 
 
 __all__ = ["AiohttpStore", "AiohttpGetResult", "AiohttpGetResultAsync"]
diff --git a/tests/test_aiohttp.py b/tests/test_aiohttp.py
index 3ee6429..9a2e2dc 100644
--- a/tests/test_aiohttp.py
+++ b/tests/test_aiohttp.py
@@ -657,3 +657,81 @@ def test_head_sync(minio_test_file):
     assert meta["path"] == minio_test_file["path"]
     assert meta["e_tag"] is not None
     assert meta["last_modified"] is not None
+
+
+# --- Nested Event Loop Handling (Jupyter compatibility) ---
+
+
+@requires_minio
+@pytest.mark.asyncio
+async def test_sync_methods_from_running_loop(minio_test_file):
+    """
+    Sync methods work when called from within a running event loop.
+
+    This simulates the Jupyter notebook environment where an event loop
+    is already running. The per-store event loop design handles this by
+    creating a dedicated thread with its own event loop for sync operations.
+    """
+    store = AiohttpStore(minio_test_file["base_url"])
+
+    # We're inside an async function, so there's a running event loop.
+    # Calling sync methods would fail with asyncio.run() but should
+    # work with the per-store event loop implementation.
+    try:
+        # Test head (sync)
+        meta = store.head(minio_test_file["path"])
+        assert meta["size"] == len(minio_test_file["content"])
+
+        # Test get (sync)
+        result = store.get(minio_test_file["path"])
+        assert result.buffer() == minio_test_file["content"]
+
+        # Test get_range (sync)
+        data = store.get_range(minio_test_file["path"], start=0, length=5)
+        assert bytes(data) == b"01234"
+
+        # Test get_ranges (sync)
+        results = store.get_ranges(
+            minio_test_file["path"], starts=[0, 10], lengths=[5, 6]
+        )
+        assert [bytes(r) for r in results] == [b"01234", b"ABCDEF"]
+
+    finally:
+        store.close()
+
+
+def test_sync_loop_not_created_outside_async():
+    """Sync loop is not created when not inside a running event loop."""
+    store = AiohttpStore("https://example.com")
+
+    # Before any sync call
+    assert store._sync_loop is None
+    assert store._sync_thread is None
+
+    # close() should be safe even if loop was never created
+    store.close()
+    assert store._sync_loop is None
+
+
+@requires_minio
+@pytest.mark.asyncio
+async def test_sync_loop_created_inside_async(minio_test_file):
+    """Sync loop is lazily created when sync method called from async context."""
+    store = AiohttpStore(minio_test_file["base_url"])
+
+    # Before sync call
+    assert store._sync_loop is None
+    assert store._sync_thread is None
+
+    # Call sync method from async context
+    _ = store.head(minio_test_file["path"])
+
+    # Sync loop should now exist
+    assert store._sync_loop is not None
+    assert store._sync_thread is not None
+    assert store._sync_thread.is_alive()
+
+    # Cleanup
+    store.close()
+    assert store._sync_loop is None
+    assert store._sync_thread is None