diff --git a/src/coreclr/pgosupport.cmake b/src/coreclr/pgosupport.cmake
index ace1fda4e9c4b7..c123229c28ff7e 100644
--- a/src/coreclr/pgosupport.cmake
+++ b/src/coreclr/pgosupport.cmake
@@ -67,3 +67,41 @@ function(add_pgo TargetName)
         endif(NOT EXISTS ${ProfilePath})
     endif(CLR_CMAKE_PGO_INSTRUMENT)
 endfunction(add_pgo)
+
+# On non-Windows platforms, PGO compile flags (-fprofile-instr-generate for instrumentation,
+# -fprofile-instr-use for optimization) must be applied at directory scope so they also affect
+# the static and object libraries (cee_wks, utilcode, coreclrpal, etc.) that are linked into
+# the final shared libraries. The per-target add_pgo function above only applies compile flags
+# to the shared library target itself, which only covers its directly compiled sources
+# (e.g. mscoree.cpp and exports.cpp for coreclr). add_pgo still sets the per-target LTO
+# link flags needed by the final shared library.
+# On Windows, PGO is handled entirely via link-time flags (/LTCG) so this isn't needed.
+if(NOT WIN32)
+    if(CLR_CMAKE_PGO_INSTRUMENT)
+        if(CMAKE_CXX_COMPILER_ID MATCHES "Clang")
+            if(UPPERCASE_CMAKE_BUILD_TYPE STREQUAL RELEASE OR UPPERCASE_CMAKE_BUILD_TYPE STREQUAL RELWITHDEBINFO)
+                add_compile_options($<$<COMPILE_LANGUAGE:C,CXX>:-fprofile-instr-generate>)
+                # All shared libraries need to link the profiling runtime to resolve
+                # instrumentation symbols from their static library dependencies.
+                add_link_options(-fprofile-instr-generate)
+            endif()
+        endif()
+    elseif(CLR_CMAKE_PGO_OPTIMIZE AND NOT CLR_CMAKE_ENABLE_SANITIZERS)
+        file(TO_NATIVE_PATH "${CLR_CMAKE_OPTDATA_PATH}/data/coreclr.profdata" _PgoGlobalProfilePath)
+        if(EXISTS "${_PgoGlobalProfilePath}")
+            if(CMAKE_CXX_COMPILER_ID MATCHES "Clang")
+                if(UPPERCASE_CMAKE_BUILD_TYPE STREQUAL RELEASE OR UPPERCASE_CMAKE_BUILD_TYPE STREQUAL RELWITHDEBINFO)
+                    check_have_lto_and_pgodata_supported("${_PgoGlobalProfilePath}")
+                    if(HAVE_LTO_AND_PGO_DATA_SUPPORTED)
+                        message(STATUS "Enabling profile guided optimizations globally for coreclr static libraries")
+                        add_compile_options(
+                            $<$<COMPILE_LANGUAGE:C,CXX>:-fprofile-instr-use=${_PgoGlobalProfilePath}>
+                            $<$<COMPILE_LANGUAGE:C,CXX>:-Wno-profile-instr-out-of-date>
+                            $<$<COMPILE_LANGUAGE:C,CXX>:-Wno-profile-instr-unprofiled>
+                        )
+                    endif()
+                endif()
+            endif()
+        endif()
+    endif()
+endif()