diff --git a/llvm/lib/Transforms/Instrumentation/MemorySanitizer.cpp b/llvm/lib/Transforms/Instrumentation/MemorySanitizer.cpp
index e6f5f75619523..3fa125d3c8ca9 100644
--- a/llvm/lib/Transforms/Instrumentation/MemorySanitizer.cpp
+++ b/llvm/lib/Transforms/Instrumentation/MemorySanitizer.cpp
@@ -888,6 +888,11 @@ static bool isUnsupportedDeviceGlobal(const GlobalVariable *G) {
     return true;
   if (G->getName().starts_with("__usid_str"))
     return true;
+  // Globals with __profd/__profc prefix are inserted by profiling pass, we
+  // don't neeed to instrument them.
+  if (G->getName().starts_with("__profd") ||
+      G->getName().starts_with("__profc"))
+    return true;
   if ((!ClSpirOffloadLocals && G->getAddressSpace() == kSpirOffloadLocalAS) ||
       G->getAddressSpace() == kSpirOffloadConstantAS)
     return true;
diff --git a/llvm/lib/Transforms/Instrumentation/ThreadSanitizer.cpp b/llvm/lib/Transforms/Instrumentation/ThreadSanitizer.cpp
index 227e4b84a0257..9a4ddb1ef57a5 100644
--- a/llvm/lib/Transforms/Instrumentation/ThreadSanitizer.cpp
+++ b/llvm/lib/Transforms/Instrumentation/ThreadSanitizer.cpp
@@ -497,6 +497,10 @@ bool ThreadSanitizerOnSpirv::isUnsupportedDeviceGlobal(
     return true;
   if (G.getName().starts_with("__usid_str"))
     return true;
+  // Globals with __profd/__profc prefix are inserted by profiling pass, we
+  // don't neeed to instrument them.
+  if (G.getName().starts_with("__profd") || G.getName().starts_with("__profc"))
+    return true;
   // Global variables have constant address space will not trigger race
   // condition.
   if (G.getAddressSpace() == kSpirOffloadConstantAS)
diff --git a/llvm/test/Instrumentation/MemorySanitizer/SPIRV/instrument_device_global.ll b/llvm/test/Instrumentation/MemorySanitizer/SPIRV/instrument_device_global.ll
index a644864d8f2c8..d3da1d8189d11 100644
--- a/llvm/test/Instrumentation/MemorySanitizer/SPIRV/instrument_device_global.ll
+++ b/llvm/test/Instrumentation/MemorySanitizer/SPIRV/instrument_device_global.ll
@@ -7,6 +7,8 @@ target triple = "spir64-unknown-unknown"
 @dev_global_no_users = dso_local addrspace(1) global { [4 x i32] } zeroinitializer
 @0 = internal global i32 0, align 4 ;nameless global
 @1 = internal global i32 0, align 4 ;nameless global
+@__profc_test.cpp__ZZZ4mainENKUlRN4sycl3_V17handlerEE_clES2_ENKUlNS0_2idILi1EEEE_clES5_ = private addrspace(1) global { ptr addrspace(1), i64 } zeroinitializer
+@__profd_test.cpp__ZZZ4mainENKUlRN4sycl3_V17handlerEE_clES2_ENKUlNS0_2idILi1EEEE_clES5_ = private addrspace(1) global { i64, i64, i64, i64, ptr, ptr, i32, [4 x i16], i32 } { i64 6860770789959664611, i64 0, i64 sub (i64 ptrtoint (ptr addrspace(1) @__profc_test.cpp__ZZZ4mainENKUlRN4sycl3_V17handlerEE_clES2_ENKUlNS0_2idILi1EEEE_clES5_ to i64), i64 ptrtoint (ptr addrspace(1) @__profd_test.cpp__ZZZ4mainENKUlRN4sycl3_V17handlerEE_clES2_ENKUlNS0_2idILi1EEEE_clES5_ to i64)), i64 0, ptr null, ptr null, i32 1, [4 x i16] zeroinitializer, i32 0 }
 
 define spir_func void @_ZZZ4mainENKUlRN4sycl3_V17handlerEE_clES2_ENKUlvE_clEv() {
 entry:
@@ -19,4 +21,6 @@ entry:
 ; CHECK: @__MsanDeviceGlobalMetadata
 ; CHECK-NOT: @__spirv_BuiltInGlobalInvocationId
 ; CHECK-NOT: @dev_global_no_users
+; CHECK-NOT: @__profc
+; CHECK-NOT: @__profd
 ; CHECK-SAME: @.str
diff --git a/llvm/test/Instrumentation/ThreadSanitizer/SPIRV/instrument_device_global.ll b/llvm/test/Instrumentation/ThreadSanitizer/SPIRV/instrument_device_global.ll
index e4cfbb5e9f747..7a7b5c95898a9 100644
--- a/llvm/test/Instrumentation/ThreadSanitizer/SPIRV/instrument_device_global.ll
+++ b/llvm/test/Instrumentation/ThreadSanitizer/SPIRV/instrument_device_global.ll
@@ -5,10 +5,14 @@ target triple = "spir64-unknown-unknown"
 @dev_global = external addrspace(1) global { [4 x i32] }
 @dev_global_no_users = dso_local addrspace(1) global { [4 x i32] } zeroinitializer
 @__spirv_BuiltInGlobalInvocationId = external addrspace(1) constant <3 x i64>
+@__profc_test.cpp__ZZZ4mainENKUlRN4sycl3_V17handlerEE_clES2_ENKUlNS0_2idILi1EEEE_clES5_ = private addrspace(1) global { ptr addrspace(1), i64 } zeroinitializer
+@__profd_test.cpp__ZZZ4mainENKUlRN4sycl3_V17handlerEE_clES2_ENKUlNS0_2idILi1EEEE_clES5_ = private addrspace(1) global { i64, i64, i64, i64, ptr, ptr, i32, [4 x i16], i32 } { i64 6860770789959664611, i64 0, i64 sub (i64 ptrtoint (ptr addrspace(1) @__profc_test.cpp__ZZZ4mainENKUlRN4sycl3_V17handlerEE_clES2_ENKUlNS0_2idILi1EEEE_clES5_ to i64), i64 ptrtoint (ptr addrspace(1) @__profd_test.cpp__ZZZ4mainENKUlRN4sycl3_V17handlerEE_clES2_ENKUlNS0_2idILi1EEEE_clES5_ to i64)), i64 0, ptr null, ptr null, i32 1, [4 x i16] zeroinitializer, i32 0 }
 
 ; CHECK: @__TsanDeviceGlobalMetadata
 ; CHECK-NOT: @dev_global_no_users
 ; CHECK-NOT: @__spirv_BuiltInGlobalInvocationId
+; CHECK-NOT: @__profc
+; CHECK-NOT: @__profd
 ; CHECK-SAME: @dev_global
 
 define spir_func void @test() {