which one is better; pre or post install optimization?

[Eaglion71]

I have been using win 10 pro but many of the software I use started to mandate for win 11. I was reluctant to install Win 11 for obvious reasons but now i have to. This PC is used for wide range of applications. I tried to install a few ISO versions to virtualbox to test but I can not install all the apps again and again for each of them to test. So I can not be sure if a debloated installation would cause any problems to a particular software.
examples of software i use, Video editing Adobe suite, 3D design fusion 360, Music studio software cakewalk and cubase, sim racing and office.

It is single person use PC and ISO will only be installed on this one. So premade ISO with unattended.xml will not be essentional for me as much as for an IT proffesional. I only need to skip MS requirements.

What is the difference between creating a debloated ISO and debloating win 11 with winhance after installing the original ISO in terms of effectiveness and performance. Which one do you recomenned?

One additional question,
In good old DOS 5.0 days, we used to have several boot floppy disks which were created with different MEM, IRC etc settings. We were using the one needed to run the program we want. After moving to Windows, the only option seemed to be creating different users with different software packs but this is not so practical. Will it be possible to create different start up configurations which only start the programs and services needed for that task.

Thanks