OFV for each individual when using est="posthoc"

[namtien0312]

Dear Dr. @mattfidler and nlmixr team,

I have a question related to deriving the OFV value for each individual with a posthoc estimation.

When using est="posthoc" option (similar to MAXEVAL = 0 in NONMEM), nlmixr estimates individual parameter based on MAP algorithm on each individual patient. Thus the estimated parameters, e.g. for patient id = 1, when performing this process for 100 patients is identical when performing said process just only for patient id = 1.

But nlmixr has denied MAP for data containing just 1 individual (error below). As a result, how can I obtain the OFV value when executing MAP for just 1 patient?

Error in eval(substitute(expr), data, enclos = parent.frame()) : 
'posthoc' estimation is for mixed effects models, try 'dynmodel' (need more than 1 individual)

Thank for your help!
Tien.

[mattfidler]

Hi @namtien0312 I would simply duplicate the single individual data and then run the "posthoc" routine.

[namtien0312]

Thank Dr. @mattfidler for the suggestion.

I have implemented this strategy before, but I found that this is time-consuming. Is there any other method available, for example, when we perform posthoc estimation for all individuals?

Thank you once again,
Tien.