diff --git a/ci-operator/config/openshift/service-ca-operator/openshift-service-ca-operator-main.yaml b/ci-operator/config/openshift/service-ca-operator/openshift-service-ca-operator-main.yaml
index 1c3fea4d517de..716581a9e9b84 100644
--- a/ci-operator/config/openshift/service-ca-operator/openshift-service-ca-operator-main.yaml
+++ b/ci-operator/config/openshift/service-ca-operator/openshift-service-ca-operator-main.yaml
@@ -62,6 +62,15 @@ tests:
     test:
     - ref: openshift-e2e-test
     workflow: ipi-aws
+- as: e2e-aws-operator-serial-disruptive-ote
+  optional: true
+  steps:
+    cluster_profile: aws
+    env:
+      TEST_SUITE: openshift/service-ca-operator/operator/serial-disruptive
+    test:
+    - ref: openshift-e2e-test
+    workflow: ipi-aws
 - as: e2e-aws-upgrade
   steps:
     cluster_profile: aws-3
diff --git a/ci-operator/config/openshift/service-ca-operator/openshift-service-ca-operator-release-4.21.yaml b/ci-operator/config/openshift/service-ca-operator/openshift-service-ca-operator-release-4.21.yaml
index 76d8f7a2d675c..46dbc6e81ef8a 100644
--- a/ci-operator/config/openshift/service-ca-operator/openshift-service-ca-operator-release-4.21.yaml
+++ b/ci-operator/config/openshift/service-ca-operator/openshift-service-ca-operator-release-4.21.yaml
@@ -62,6 +62,15 @@ tests:
     test:
     - ref: openshift-e2e-test
     workflow: ipi-aws
+- as: e2e-aws-operator-serial-disruptive-ote
+  optional: true
+  steps:
+    cluster_profile: aws
+    env:
+      TEST_SUITE: openshift/service-ca-operator/operator/serial-disruptive
+    test:
+    - ref: openshift-e2e-test
+    workflow: ipi-aws
 - as: e2e-aws-upgrade
   steps:
     cluster_profile: aws-3
diff --git a/ci-operator/config/openshift/service-ca-operator/openshift-service-ca-operator-release-4.22.yaml b/ci-operator/config/openshift/service-ca-operator/openshift-service-ca-operator-release-4.22.yaml
index 58e7ed99d22f5..a109d54715175 100644
--- a/ci-operator/config/openshift/service-ca-operator/openshift-service-ca-operator-release-4.22.yaml
+++ b/ci-operator/config/openshift/service-ca-operator/openshift-service-ca-operator-release-4.22.yaml
@@ -63,6 +63,15 @@ tests:
     test:
     - ref: openshift-e2e-test
     workflow: ipi-aws
+- as: e2e-aws-operator-serial-disruptive-ote
+  optional: true
+  steps:
+    cluster_profile: aws
+    env:
+      TEST_SUITE: openshift/service-ca-operator/operator/serial-disruptive
+    test:
+    - ref: openshift-e2e-test
+    workflow: ipi-aws
 - as: e2e-aws-upgrade
   steps:
     cluster_profile: aws-3
diff --git a/ci-operator/jobs/openshift/service-ca-operator/openshift-service-ca-operator-main-presubmits.yaml b/ci-operator/jobs/openshift/service-ca-operator/openshift-service-ca-operator-main-presubmits.yaml
index 9aaf3b6b8fe48..3ff1a3392090a 100644
--- a/ci-operator/jobs/openshift/service-ca-operator/openshift-service-ca-operator-main-presubmits.yaml
+++ b/ci-operator/jobs/openshift/service-ca-operator/openshift-service-ca-operator-main-presubmits.yaml
@@ -144,6 +144,79 @@ presubmits:
         secret:
           secretName: result-aggregator
     trigger: (?m)^/test( | .* )e2e-aws-operator,?($|\s.*)
+  - agent: kubernetes
+    always_run: true
+    branches:
+    - ^main$
+    - ^main-
+    cluster: build05
+    context: ci/prow/e2e-aws-operator-serial-disruptive-ote
+    decorate: true
+    labels:
+      ci-operator.openshift.io/cloud: aws
+      ci-operator.openshift.io/cloud-cluster-profile: aws
+      ci.openshift.io/generator: prowgen
+      pj-rehearse.openshift.io/can-be-rehearsed: "true"
+    name: pull-ci-openshift-service-ca-operator-main-e2e-aws-operator-serial-disruptive-ote
+    optional: true
+    rerun_command: /test e2e-aws-operator-serial-disruptive-ote
+    spec:
+      containers:
+      - args:
+        - --gcs-upload-secret=/secrets/gcs/service-account.json
+        - --image-import-pull-secret=/etc/pull-secret/.dockerconfigjson
+        - --lease-server-credentials-file=/etc/boskos/credentials
+        - --report-credentials-file=/etc/report/credentials
+        - --secret-dir=/secrets/ci-pull-credentials
+        - --target=e2e-aws-operator-serial-disruptive-ote
+        command:
+        - ci-operator
+        image: quay-proxy.ci.openshift.org/openshift/ci:ci_ci-operator_latest
+        imagePullPolicy: Always
+        name: ""
+        resources:
+          requests:
+            cpu: 10m
+        volumeMounts:
+        - mountPath: /etc/boskos
+          name: boskos
+          readOnly: true
+        - mountPath: /secrets/ci-pull-credentials
+          name: ci-pull-credentials
+          readOnly: true
+        - mountPath: /secrets/gcs
+          name: gcs-credentials
+          readOnly: true
+        - mountPath: /secrets/manifest-tool
+          name: manifest-tool-local-pusher
+          readOnly: true
+        - mountPath: /etc/pull-secret
+          name: pull-secret
+          readOnly: true
+        - mountPath: /etc/report
+          name: result-aggregator
+          readOnly: true
+      serviceAccountName: ci-operator
+      volumes:
+      - name: boskos
+        secret:
+          items:
+          - key: credentials
+            path: credentials
+          secretName: boskos-credentials
+      - name: ci-pull-credentials
+        secret:
+          secretName: ci-pull-credentials
+      - name: manifest-tool-local-pusher
+        secret:
+          secretName: manifest-tool-local-pusher
+      - name: pull-secret
+        secret:
+          secretName: registry-pull-credentials
+      - name: result-aggregator
+        secret:
+          secretName: result-aggregator
+    trigger: (?m)^/test( | .* )e2e-aws-operator-serial-disruptive-ote,?($|\s.*)
   - agent: kubernetes
     always_run: true
     branches:
diff --git a/ci-operator/jobs/openshift/service-ca-operator/openshift-service-ca-operator-release-4.21-presubmits.yaml b/ci-operator/jobs/openshift/service-ca-operator/openshift-service-ca-operator-release-4.21-presubmits.yaml
index d0f2b380f2696..cce59dca618c0 100644
--- a/ci-operator/jobs/openshift/service-ca-operator/openshift-service-ca-operator-release-4.21-presubmits.yaml
+++ b/ci-operator/jobs/openshift/service-ca-operator/openshift-service-ca-operator-release-4.21-presubmits.yaml
@@ -144,6 +144,79 @@ presubmits:
         secret:
           secretName: result-aggregator
     trigger: (?m)^/test( | .* )e2e-aws-operator,?($|\s.*)
+  - agent: kubernetes
+    always_run: true
+    branches:
+    - ^release-4\.21$
+    - ^release-4\.21-
+    cluster: build06
+    context: ci/prow/e2e-aws-operator-serial-disruptive-ote
+    decorate: true
+    labels:
+      ci-operator.openshift.io/cloud: aws
+      ci-operator.openshift.io/cloud-cluster-profile: aws
+      ci.openshift.io/generator: prowgen
+      pj-rehearse.openshift.io/can-be-rehearsed: "true"
+    name: pull-ci-openshift-service-ca-operator-release-4.21-e2e-aws-operator-serial-disruptive-ote
+    optional: true
+    rerun_command: /test e2e-aws-operator-serial-disruptive-ote
+    spec:
+      containers:
+      - args:
+        - --gcs-upload-secret=/secrets/gcs/service-account.json
+        - --image-import-pull-secret=/etc/pull-secret/.dockerconfigjson
+        - --lease-server-credentials-file=/etc/boskos/credentials
+        - --report-credentials-file=/etc/report/credentials
+        - --secret-dir=/secrets/ci-pull-credentials
+        - --target=e2e-aws-operator-serial-disruptive-ote
+        command:
+        - ci-operator
+        image: quay-proxy.ci.openshift.org/openshift/ci:ci_ci-operator_latest
+        imagePullPolicy: Always
+        name: ""
+        resources:
+          requests:
+            cpu: 10m
+        volumeMounts:
+        - mountPath: /etc/boskos
+          name: boskos
+          readOnly: true
+        - mountPath: /secrets/ci-pull-credentials
+          name: ci-pull-credentials
+          readOnly: true
+        - mountPath: /secrets/gcs
+          name: gcs-credentials
+          readOnly: true
+        - mountPath: /secrets/manifest-tool
+          name: manifest-tool-local-pusher
+          readOnly: true
+        - mountPath: /etc/pull-secret
+          name: pull-secret
+          readOnly: true
+        - mountPath: /etc/report
+          name: result-aggregator
+          readOnly: true
+      serviceAccountName: ci-operator
+      volumes:
+      - name: boskos
+        secret:
+          items:
+          - key: credentials
+            path: credentials
+          secretName: boskos-credentials
+      - name: ci-pull-credentials
+        secret:
+          secretName: ci-pull-credentials
+      - name: manifest-tool-local-pusher
+        secret:
+          secretName: manifest-tool-local-pusher
+      - name: pull-secret
+        secret:
+          secretName: registry-pull-credentials
+      - name: result-aggregator
+        secret:
+          secretName: result-aggregator
+    trigger: (?m)^/test( | .* )e2e-aws-operator-serial-disruptive-ote,?($|\s.*)
   - agent: kubernetes
     always_run: true
     branches:
diff --git a/ci-operator/jobs/openshift/service-ca-operator/openshift-service-ca-operator-release-4.22-presubmits.yaml b/ci-operator/jobs/openshift/service-ca-operator/openshift-service-ca-operator-release-4.22-presubmits.yaml
index e10f10069879e..5995c13a8d0de 100644
--- a/ci-operator/jobs/openshift/service-ca-operator/openshift-service-ca-operator-release-4.22-presubmits.yaml
+++ b/ci-operator/jobs/openshift/service-ca-operator/openshift-service-ca-operator-release-4.22-presubmits.yaml
@@ -144,6 +144,79 @@ presubmits:
         secret:
           secretName: result-aggregator
     trigger: (?m)^/test( | .* )e2e-aws-operator,?($|\s.*)
+  - agent: kubernetes
+    always_run: true
+    branches:
+    - ^release-4\.22$
+    - ^release-4\.22-
+    cluster: build06
+    context: ci/prow/e2e-aws-operator-serial-disruptive-ote
+    decorate: true
+    labels:
+      ci-operator.openshift.io/cloud: aws
+      ci-operator.openshift.io/cloud-cluster-profile: aws
+      ci.openshift.io/generator: prowgen
+      pj-rehearse.openshift.io/can-be-rehearsed: "true"
+    name: pull-ci-openshift-service-ca-operator-release-4.22-e2e-aws-operator-serial-disruptive-ote
+    optional: true
+    rerun_command: /test e2e-aws-operator-serial-disruptive-ote
+    spec:
+      containers:
+      - args:
+        - --gcs-upload-secret=/secrets/gcs/service-account.json
+        - --image-import-pull-secret=/etc/pull-secret/.dockerconfigjson
+        - --lease-server-credentials-file=/etc/boskos/credentials
+        - --report-credentials-file=/etc/report/credentials
+        - --secret-dir=/secrets/ci-pull-credentials
+        - --target=e2e-aws-operator-serial-disruptive-ote
+        command:
+        - ci-operator
+        image: quay-proxy.ci.openshift.org/openshift/ci:ci_ci-operator_latest
+        imagePullPolicy: Always
+        name: ""
+        resources:
+          requests:
+            cpu: 10m
+        volumeMounts:
+        - mountPath: /etc/boskos
+          name: boskos
+          readOnly: true
+        - mountPath: /secrets/ci-pull-credentials
+          name: ci-pull-credentials
+          readOnly: true
+        - mountPath: /secrets/gcs
+          name: gcs-credentials
+          readOnly: true
+        - mountPath: /secrets/manifest-tool
+          name: manifest-tool-local-pusher
+          readOnly: true
+        - mountPath: /etc/pull-secret
+          name: pull-secret
+          readOnly: true
+        - mountPath: /etc/report
+          name: result-aggregator
+          readOnly: true
+      serviceAccountName: ci-operator
+      volumes:
+      - name: boskos
+        secret:
+          items:
+          - key: credentials
+            path: credentials
+          secretName: boskos-credentials
+      - name: ci-pull-credentials
+        secret:
+          secretName: ci-pull-credentials
+      - name: manifest-tool-local-pusher
+        secret:
+          secretName: manifest-tool-local-pusher
+      - name: pull-secret
+        secret:
+          secretName: registry-pull-credentials
+      - name: result-aggregator
+        secret:
+          secretName: result-aggregator
+    trigger: (?m)^/test( | .* )e2e-aws-operator-serial-disruptive-ote,?($|\s.*)
   - agent: kubernetes
     always_run: true
     branches: