diff --git a/.github/CONTRIBUTING.md b/.github/CONTRIBUTING.md
index fbdf075f03..a09b630a21 100644
--- a/.github/CONTRIBUTING.md
+++ b/.github/CONTRIBUTING.md
@@ -165,7 +165,7 @@ The valid options are:
 * Use `cmake --build build -j12` to build with 12 cores (for example).
 * Use `-G` and the name of a generator to use something different. `cmake
   --help` lists the generators available.
-      - On Unix, setting `CMAKE_GENERATER=Ninja` in your environment will give
+      - On Unix, setting `CMAKE_GENERATOR=Ninja` in your environment will give
         you automatic multithreading on all your CMake projects!
 * Open the `CMakeLists.txt` with QtCreator to generate for that IDE.
 * You can use `-DCMAKE_EXPORT_COMPILE_COMMANDS=ON` to generate the `.json` file
diff --git a/.pre-commit-config.yaml b/.pre-commit-config.yaml
index ba6f3829ae..aa7b58cc40 100644
--- a/.pre-commit-config.yaml
+++ b/.pre-commit-config.yaml
@@ -115,9 +115,16 @@ repos:
   rev: "v2.4.1"
   hooks:
   - id: codespell
-    exclude: ".supp$"
+    exclude: "(.supp|^pyproject.toml)$"
     args: ["-x.codespell-ignore-lines", "-Lccompiler,intstruct"]
 
+# Also check spelling
+- repo: https://github.com/crate-ci/typos
+  rev: v1.40.0
+  hooks:
+  - id: typos
+    args: []
+
 # Check for common shell mistakes
 - repo: https://github.com/shellcheck-py/shellcheck-py
   rev: "v0.11.0.1"
diff --git a/docs/advanced/embedding.rst b/docs/advanced/embedding.rst
index 3ac0579385..7d770faa21 100644
--- a/docs/advanced/embedding.rst
+++ b/docs/advanced/embedding.rst
@@ -302,7 +302,7 @@ Activating a Sub-interpreter
 
 Once a sub-interpreter is created, you can "activate" it on a thread (and
 acquire its GIL) by creating a :class:`subinterpreter_scoped_activate`
-instance and passing it the sub-intepreter to be activated.  The function
+instance and passing it the sub-interpreter to be activated.  The function
 will acquire the sub-interpreter's GIL and make the sub-interpreter the
 current active interpreter on the current thread for the lifetime of the
 instance. When the :class:`subinterpreter_scoped_activate` instance goes out
diff --git a/docs/changelog.md b/docs/changelog.md
index c8d631879f..4bf23a697f 100644
--- a/docs/changelog.md
+++ b/docs/changelog.md
@@ -167,7 +167,7 @@ New Features:
   [#5665](https://github.com/pybind/pybind11/pull/5665) and consolidate code
   [#5670](https://github.com/pybind/pybind11/pull/5670).
 
-- Added API in `pybind11/subinterpreter.h` for embedding sub-intepreters (requires Python 3.12+).
+- Added API in `pybind11/subinterpreter.h` for embedding sub-interpreters (requires Python 3.12+).
   [#5666](https://github.com/pybind/pybind11/pull/5666)
 
 - `py::native_enum` was added, for conversions between Python's native
@@ -1213,7 +1213,7 @@ Performance and style:
 - Optimize Eigen sparse matrix casting by removing unnecessary
   temporary. [#4064](https://github.com/pybind/pybind11/pull/4064)
 - Avoid potential implicit copy/assignment constructors causing double
-  free in `strdup_gaurd`.
+  free in `strdup_guard`.
   [#3905](https://github.com/pybind/pybind11/pull/3905)
 - Enable clang-tidy checks `misc-definitions-in-headers`,
   `modernize-loop-convert`, and `modernize-use-nullptr`.
diff --git a/pyproject.toml b/pyproject.toml
index 274de222af..7a12eed1ac 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -184,3 +184,26 @@ isort.required-imports = ["from __future__ import annotations"]
 
 [tool.repo-review]
 ignore = ["PP"]
+
+[tool.typos]
+files.extend-exclude = ["/cpython"]
+
+[tool.typos.default.extend-identifiers]
+ser_no = "ser_no"
+SerNo = "SerNo"
+StrLits = "StrLits"
+
+[tool.typos.default.extend-words]
+nd = "nd"
+valu = "valu"
+fo = "fo"
+quater = "quater"
+optin = "optin"
+othr = "othr"
+
+#[tool.typos.type.cpp.extend-words]
+setp = "setp"
+ot = "ot"
+
+[tool.typos.type.json.extend-words]
+ba = "ba"
diff --git a/tests/conftest.py b/tests/conftest.py
index 39de4e1381..9d9815b88c 100644
--- a/tests/conftest.py
+++ b/tests/conftest.py
@@ -304,10 +304,10 @@ def backport_typehints() -> Callable[[SanitizedString], SanitizedString]:
     if sys.version_info < (3, 10):
         d["typing_extensions.TypeGuard"] = "typing.TypeGuard"
 
-    def backport(sanatized_string: SanitizedString) -> SanitizedString:
+    def backport(sanitized_string: SanitizedString) -> SanitizedString:
         for old, new in d.items():
-            sanatized_string.string = sanatized_string.string.replace(old, new)
+            sanitized_string.string = sanitized_string.string.replace(old, new)
 
-        return sanatized_string
+        return sanitized_string
 
     return backport
diff --git a/tests/test_docstring_options.py b/tests/test_docstring_options.py
index 802a1ec9e5..ffd1a739d6 100644
--- a/tests/test_docstring_options.py
+++ b/tests/test_docstring_options.py
@@ -48,7 +48,7 @@ def test_docstring_options():
     assert not m.DocstringTestFoo.__doc__
     assert not m.DocstringTestFoo.value_prop.__doc__
 
-    # Check existig behaviour of enum docstings
+    # Check existing behaviour of enum docstings
     assert (
         m.DocstringTestEnum1.__doc__
         == "Enum docstring\n\nMembers:\n\n  Member1\n\n  Member2"