diff --git a/Python/emscripten_syscalls.c b/Python/emscripten_syscalls.c
new file mode 100644
index 00000000000000..7875bfc8fe56ae
--- /dev/null
+++ b/Python/emscripten_syscalls.c
@@ -0,0 +1,19 @@
+#include "emscripten.h"
+
+// If we're running in node, report the UID of the user in the native system as
+// the UID of the user. Since the nodefs will report the uid correctly, if we
+// don't make getuid report it correctly too we'll see some permission errors.
+// Normally __syscall_getuid32 is a stub that always returns 0 but it is
+// defined with weak linkage so we can override it.
+EM_JS(int, __syscall_getuid32_js, (void), {
+    // If we're in node and we can, report the native uid
+    if (typeof process !== "undefined" && typeof process.getuid === "function") {
+        return process.getuid();
+    }
+    // Fall back to the stub case of returning 0.
+    return 0;
+})
+
+int __syscall_getuid32(void) {
+    return __syscall_getuid32_js();
+}
diff --git a/configure b/configure
index 94a0b810333ce9..cc868bf47d441c 100755
--- a/configure
+++ b/configure
@@ -19060,7 +19060,7 @@ PLATFORM_OBJS=
 case $ac_sys_system in #(
   Emscripten) :
 
-    as_fn_append PLATFORM_OBJS ' Python/emscripten_signal.o Python/emscripten_trampoline.o'
+    as_fn_append PLATFORM_OBJS ' Python/emscripten_signal.o Python/emscripten_trampoline.o Python/emscripten_syscalls.o'
     as_fn_append PLATFORM_HEADERS ' $(srcdir)/Include/internal/pycore_emscripten_signal.h $(srcdir)/Include/internal/pycore_emscripten_trampoline.h'
    ;; #(
   *) :
diff --git a/configure.ac b/configure.ac
index ade71bc011eb87..727bfb1b3bf681 100644
--- a/configure.ac
+++ b/configure.ac
@@ -5119,7 +5119,7 @@ PLATFORM_OBJS=
 
 AS_CASE([$ac_sys_system],
   [Emscripten], [
-    AS_VAR_APPEND([PLATFORM_OBJS], [' Python/emscripten_signal.o Python/emscripten_trampoline.o'])
+    AS_VAR_APPEND([PLATFORM_OBJS], [' Python/emscripten_signal.o Python/emscripten_trampoline.o Python/emscripten_syscalls.o'])
     AS_VAR_APPEND([PLATFORM_HEADERS], [' $(srcdir)/Include/internal/pycore_emscripten_signal.h $(srcdir)/Include/internal/pycore_emscripten_trampoline.h'])
   ],
 )