diff --git a/packages/community-cli-plugin/src/utils/loadMetroConfig.js b/packages/community-cli-plugin/src/utils/loadMetroConfig.js
index a41b028fa29a..43d9e4126af7 100644
--- a/packages/community-cli-plugin/src/utils/loadMetroConfig.js
+++ b/packages/community-cli-plugin/src/utils/loadMetroConfig.js
@@ -60,17 +60,16 @@ function getCommunityCliDefaultConfig(
   return {
     resolver,
     serializer: {
-      // We can include multiple copies of setup-env here because Metro will
+      // We can include multiple copies of InitializeCore here because metro will
       // only add ones that are already part of the bundle
       getModulesRunBeforeMainModule: () => [
-        // NOTE: ctx.reactNativePath is an absolute path, therefore we need to
-        // reference setup-env.js here by exact path specifier.
-        require.resolve(path.join(ctx.reactNativePath, 'src/setup-env.js'), {
-          paths: [ctx.root],
-        }),
+        require.resolve(
+          path.join(ctx.reactNativePath, 'Libraries/Core/InitializeCore'),
+          {paths: [ctx.root]},
+        ),
         ...outOfTreePlatforms.map(platform =>
           require.resolve(
-            `${ctx.platforms[platform].npmPackageName}/setup-env`,
+            `${ctx.platforms[platform].npmPackageName}/Libraries/Core/InitializeCore`,
             {paths: [ctx.root]},
           ),
         ),
diff --git a/packages/metro-config/src/index.flow.js b/packages/metro-config/src/index.flow.js
index dcac214b3978..03a9aed5ace4 100644
--- a/packages/metro-config/src/index.flow.js
+++ b/packages/metro-config/src/index.flow.js
@@ -61,7 +61,7 @@ export function getDefaultConfig(projectRoot: string): ConfigT {
     serializer: {
       // Note: This option is overridden in cli-plugin-metro (getOverrideConfig)
       getModulesRunBeforeMainModule: () => [
-        require.resolve('react-native/setup-env'),
+        require.resolve('react-native/Libraries/Core/InitializeCore'),
       ],
       getPolyfills: () => require('@react-native/js-polyfills')(),
       isThirdPartyModule({path: modulePath}: Readonly<{path: string, ...}>) {