diff --git a/packages/smithy-http/src/smithy_http/aio/protocols.py b/packages/smithy-http/src/smithy_http/aio/protocols.py
index e5591923..e842bec8 100644
--- a/packages/smithy-http/src/smithy_http/aio/protocols.py
+++ b/packages/smithy-http/src/smithy_http/aio/protocols.py
@@ -1,9 +1,10 @@
 import os
+from collections.abc import AsyncIterable
 from inspect import iscoroutinefunction
-from io import BytesIO
 from typing import Any
 
-from smithy_core.aio.interfaces import ClientProtocol
+from smithy_core.aio.interfaces import AsyncByteStream, ClientProtocol
+from smithy_core.aio.interfaces import StreamingBlob as AsyncStreamingBlob
 from smithy_core.codecs import Codec
 from smithy_core.deserializers import DeserializeableShape
 from smithy_core.documents import TypeRegistry
@@ -109,35 +110,45 @@ async def deserialize_response[
         error_registry: TypeRegistry,
         context: TypedProperties,
     ) -> OperationOutput:
-        body = response.body
-
-        # if body is not streaming and is async, we have to buffer it
-        if not operation.output_stream_member and not is_streaming_blob(body):
-            if (
-                read := getattr(body, "read", None)
-            ) is not None and iscoroutinefunction(read):
-                body = BytesIO(await read())
-
         if not self._is_success(operation, context, response):
             raise await self._create_error(
                 operation=operation,
                 request=request,
                 response=response,
-                response_body=body,  # type: ignore
+                response_body=await self._buffer_async_body(response.body),
                 error_registry=error_registry,
                 context=context,
             )
 
+        # if body is not streaming and is async, we have to buffer it
+        body: SyncStreamingBlob | None = None
+        if not operation.output_stream_member and not is_streaming_blob(body):
+            body = await self._buffer_async_body(response.body)
+
         # TODO(optimization): response binding cache like done in SJ
         deserializer = HTTPResponseDeserializer(
             payload_codec=self.payload_codec,
             http_trait=operation.schema.expect_trait(HTTPTrait),
             response=response,
-            body=body,  # type: ignore
+            body=body,
         )
 
         return operation.output.deserialize(deserializer)
 
+    async def _buffer_async_body(self, stream: AsyncStreamingBlob) -> SyncStreamingBlob:
+        match stream:
+            case AsyncByteStream():
+                if not iscoroutinefunction(stream.read):
+                    return stream  # type: ignore
+                return await stream.read()
+            case AsyncIterable():
+                full = b""
+                async for chunk in stream:
+                    full += chunk
+                return full
+            case _:
+                return stream
+
     def _is_success(
         self,
         operation: APIOperation[Any, Any],