de.test.design_matrix(): allow no absortion of first factor level into offset

[davidsebfischer]

Relevant for constraint scenarios.

[davidsebfischer]

Requested by @LuckyMD

[LuckyMD]

Is it just this?
dmat_cond = pat.dmatrix("condition", adata.obs, return_type='dataframe')
dmat_samp = pat.dmatrix("sample-1", adata.obs, return_type='dataframe')
dmat_chip = pat.dmatrix("chip-1", adata.obs, return_type='dataframe')
dmat = dmat_cond.join(dmat_samp).join(dmat_chip)

[davidsebfischer]

Yes @LuckyMD, this is how you would do it in patsy.