diff --git a/docs/caching-architecture.md b/docs/caching-architecture.md
index b4aa9c1..b74ab72 100644
--- a/docs/caching-architecture.md
+++ b/docs/caching-architecture.md
@@ -235,6 +235,117 @@ For workloads requiring cross-worker cache sharing, consider:
 - Shared filesystem caching
 - Restructuring workloads to minimize cross-worker file access
 
+### Pickling and Serialization
+
+`CachingReadableStore` supports Python's pickle protocol for use with multiprocessing and distributed frameworks. When a `CachingReadableStore` is pickled and unpickled (e.g., sent to a worker process), it is **recreated with an empty cache**.
+
+```python
+import pickle
+from obspec_utils.cache import CachingReadableStore
+
+# Main process: create and populate cache
+cached_store = CachingReadableStore(store, max_size=256 * 1024 * 1024)
+cached_store.get("file1.nc")  # Cached
+cached_store.get("file2.nc")  # Cached
+print(cached_store.cache_size)  # Non-zero
+
+# Simulate sending to worker (pickle roundtrip)
+restored = pickle.loads(pickle.dumps(cached_store))
+
+# Worker receives store with empty cache
+print(restored.cache_size)  # 0
+print(restored._max_size)   # 256 * 1024 * 1024 (preserved)
+```
+
+**Design rationale:**
+
+1. **Cache contents are not serialized**: Serializing the full cache would defeat the purpose of distributed processing—workers would receive potentially huge payloads, and the data may not even be relevant to their partition.
+
+2. **Fresh cache per worker**: Each worker builds its own cache based on its workload. For file-partitioned workloads (common in data processing), this is optimal—each worker caches only the files it processes.
+
+3. **Configuration is preserved**: The `max_size` and underlying store are preserved, so workers use the same caching policy as the main process.
+
+**Requirements for pickling:**
+
+The underlying store (`_store`) must also be picklable. For cloud stores, this typically means using stores that can be reconstructed from configuration:
+
+```python
+# Works: store can be pickled (configuration-based)
+from obstore.store import S3Store
+s3_store = S3Store(bucket="my-bucket", region="us-east-1")
+cached = CachingReadableStore(s3_store)
+pickle.dumps(cached)  # OK
+
+# May not work: some Rust-backed stores aren't picklable
+from obstore.store import MemoryStore
+mem_store = MemoryStore()
+cached = CachingReadableStore(mem_store)
+pickle.dumps(cached)  # TypeError: cannot pickle 'MemoryStore' object
+```
+
+### Distributed Usage Patterns
+
+#### Pattern 1: File-Partitioned Workloads (Recommended)
+
+When each worker processes a distinct set of files, per-worker caching works well:
+
+```python
+from concurrent.futures import ProcessPoolExecutor
+from obspec_utils.cache import CachingReadableStore
+
+def process_files(cached_store, file_paths):
+    """Each worker gets its own cache, processes its own files."""
+    results = []
+    for path in file_paths:
+        # First access: fetch from network, cache locally
+        data = cached_store.get(path)
+        # Subsequent accesses to same file: served from cache
+        result = analyze(data)
+        results.append(result)
+    return results
+
+# Create cached store in main process
+store = S3Store(bucket="my-bucket")
+cached_store = CachingReadableStore(store, max_size=512 * 1024 * 1024)
+
+# Partition files across workers
+all_files = ["file1.nc", "file2.nc", "file3.nc", "file4.nc"]
+partitions = [all_files[:2], all_files[2:]]
+
+with ProcessPoolExecutor(max_workers=2) as executor:
+    futures = [
+        executor.submit(process_files, cached_store, partition)
+        for partition in partitions
+    ]
+    results = [f.result() for f in futures]
+```
+
+#### Pattern 2: Dask Distributed
+
+With Dask, the cached store is serialized to each worker:
+
+```python
+import dask
+from dask.distributed import Client
+from obspec_utils.cache import CachingReadableStore
+
+client = Client()
+
+store = S3Store(bucket="my-bucket")
+cached_store = CachingReadableStore(store)
+
+@dask.delayed
+def process_file(cached_store, path):
+    # Worker receives cached_store with empty cache
+    # Cache builds up as this worker processes files
+    data = cached_store.get(path)
+    return analyze(data)
+
+tasks = [process_file(cached_store, f) for f in file_list]
+results = dask.compute(*tasks)
+```
+
+
 ## Decision Guide
 
 ### Which reader should I use?
diff --git a/src/obspec_utils/cache.py b/src/obspec_utils/cache.py
index 0d8cf7e..368e26c 100644
--- a/src/obspec_utils/cache.py
+++ b/src/obspec_utils/cache.py
@@ -113,6 +113,20 @@ def __getattr__(self, name: str) -> Any:
         """
         return getattr(self._store, name)
 
+    def __reduce__(self):
+        """Support pickling for multiprocessing and distributed frameworks.
+
+        Returns a fresh instance with an empty cache. This is intentional:
+        serializing the full cache contents would be inefficient for distributed
+        workloads where each worker typically processes different files.
+
+        The underlying store and max_size configuration are preserved.
+        """
+        return (
+            self.__class__,
+            (self._store, self._max_size),
+        )
+
     def _add_to_cache(self, path: str, data: bytes) -> None:
         """Add data to cache, evicting LRU entries if needed.
 
diff --git a/tests/test_cache.py b/tests/test_cache.py
index bde855c..c273cfe 100644
--- a/tests/test_cache.py
+++ b/tests/test_cache.py
@@ -1,5 +1,6 @@
 """Tests for CachingReadableStore."""
 
+import pickle
 import threading
 from concurrent.futures import ThreadPoolExecutor
 
@@ -389,3 +390,189 @@ def test_forwards_unknown_attributes(self):
         # This tests that __getattr__ forwards correctly
         assert hasattr(cached, "put")  # MemoryStore has put
         assert hasattr(cached, "delete")  # MemoryStore has delete
+
+
+class PicklableStore:
+    """A simple picklable store for testing pickle support.
+
+    MemoryStore from obstore is Rust-backed and not picklable.
+    This pure-Python store allows testing CachingReadableStore's pickle support.
+    """
+
+    def __init__(self, data: dict[str, bytes] | None = None):
+        self._data = data or {}
+
+    def put(self, path: str, data: bytes) -> None:
+        self._data[path] = data
+
+    def get(self, path: str, *, options=None):
+        return _PicklableGetResult(self._data[path])
+
+    async def get_async(self, path: str, *, options=None):
+        return _PicklableGetResultAsync(self._data[path])
+
+    def get_range(
+        self,
+        path: str,
+        *,
+        start: int,
+        end: int | None = None,
+        length: int | None = None,
+    ):
+        data = self._data[path]
+        if end is not None:
+            return data[start:end]
+        elif length is not None:
+            return data[start : start + length]
+        return data[start:]
+
+    async def get_range_async(
+        self,
+        path: str,
+        *,
+        start: int,
+        end: int | None = None,
+        length: int | None = None,
+    ):
+        return self.get_range(path, start=start, end=end, length=length)
+
+    def get_ranges(self, path: str, *, starts, ends=None, lengths=None):
+        if ends is not None:
+            return [self._data[path][s:e] for s, e in zip(starts, ends)]
+        elif lengths is not None:
+            return [
+                self._data[path][start : start + length]
+                for start, length in zip(starts, lengths)
+            ]
+        raise ValueError("Must provide ends or lengths")
+
+    async def get_ranges_async(self, path: str, *, starts, ends=None, lengths=None):
+        return self.get_ranges(path, starts=starts, ends=ends, lengths=lengths)
+
+
+class _PicklableGetResult:
+    """Mock GetResult for PicklableStore."""
+
+    def __init__(self, data: bytes):
+        self._data = data
+
+    def buffer(self):
+        return self._data
+
+
+class _PicklableGetResultAsync:
+    """Mock async GetResult for PicklableStore."""
+
+    def __init__(self, data: bytes):
+        self._data = data
+
+    async def buffer_async(self):
+        return self._data
+
+
+class TestPickling:
+    """Tests for pickling support (needed for multiprocessing/distributed)."""
+
+    def test_pickle_roundtrip(self):
+        """CachingReadableStore can be pickled and unpickled."""
+        source = PicklableStore()
+        source.put("file.txt", b"hello world")
+
+        cached = CachingReadableStore(source, max_size=128 * 1024 * 1024)
+
+        # Pickle and unpickle
+        pickled = pickle.dumps(cached)
+        restored = pickle.loads(pickled)
+
+        assert isinstance(restored, CachingReadableStore)
+
+    def test_pickle_preserves_store_and_max_size(self):
+        """Unpickled store preserves underlying store and max_size."""
+        source = PicklableStore()
+        source.put("file.txt", b"hello world")
+
+        custom_max_size = 64 * 1024 * 1024
+        cached = CachingReadableStore(source, max_size=custom_max_size)
+
+        restored = pickle.loads(pickle.dumps(cached))
+
+        # max_size should be preserved
+        assert restored._max_size == custom_max_size
+
+        # underlying store should work (can fetch data)
+        result = restored.get("file.txt")
+        assert bytes(result.buffer()) == b"hello world"
+
+    def test_pickle_creates_empty_cache(self):
+        """Unpickled store has a fresh empty cache."""
+        source = PicklableStore()
+        source.put("file.txt", b"hello world")
+        source.put("file2.txt", b"more data")
+
+        cached = CachingReadableStore(source)
+
+        # Populate the cache
+        cached.get("file.txt")
+        cached.get("file2.txt")
+        assert cached.cache_size > 0
+        assert len(cached.cached_paths) == 2
+
+        # Pickle and unpickle
+        restored = pickle.loads(pickle.dumps(cached))
+
+        # Restored cache should be empty
+        assert restored.cache_size == 0
+        assert len(restored.cached_paths) == 0
+
+    def test_pickle_restored_store_is_functional(self):
+        """Restored store can cache new data normally."""
+        source = PicklableStore()
+        source.put("file.txt", b"hello world")
+
+        cached = CachingReadableStore(source, max_size=100)
+        cached.get("file.txt")
+
+        restored = pickle.loads(pickle.dumps(cached))
+
+        # Restored store should be able to fetch and cache
+        result = restored.get("file.txt")
+        assert bytes(result.buffer()) == b"hello world"
+        assert "file.txt" in restored.cached_paths
+        assert restored.cache_size == len(b"hello world")
+
+    def test_pickle_restored_store_lru_works(self):
+        """Restored store has working LRU eviction."""
+        source = PicklableStore()
+        source.put("file1.txt", b"a" * 100)
+        source.put("file2.txt", b"b" * 100)
+        source.put("file3.txt", b"c" * 100)
+
+        cached = CachingReadableStore(source, max_size=200)
+
+        restored = pickle.loads(pickle.dumps(cached))
+
+        # Cache two files
+        restored.get("file1.txt")
+        restored.get("file2.txt")
+        assert restored.cached_paths == ["file1.txt", "file2.txt"]
+
+        # Third file should evict first
+        restored.get("file3.txt")
+        assert restored.cached_paths == ["file2.txt", "file3.txt"]
+
+    def test_pickle_multiple_protocols(self):
+        """Pickling works with different pickle protocols."""
+        source = PicklableStore()
+        source.put("file.txt", b"hello world")
+
+        cached = CachingReadableStore(source)
+        cached.get("file.txt")
+
+        # Test all available protocols
+        for protocol in range(pickle.HIGHEST_PROTOCOL + 1):
+            pickled = pickle.dumps(cached, protocol=protocol)
+            restored = pickle.loads(pickled)
+
+            assert restored.cache_size == 0  # Fresh cache
+            result = restored.get("file.txt")
+            assert bytes(result.buffer()) == b"hello world"