Cl-Open is a program that allows make Open and Closed shearches with Comet and MSFragger, and improve the outputs of any OpenSearch with ones from ClosedSearch
This version is an alpha version, so not all options are active or working correctly. Please contact us if you encounter any issues.
Cl-Open includes MSFragger and Comet for performing closed searches with both tools and open searches with MSFragger. Additionally, it includes a kit to merge open and closed searches from other sources. The selection of the best candidates is based on xcorr across all candidates. The functions included for merging are:
ProteomeDiscoverer-CometPTM Comet-CometPTM MSFragger-MSFragger
However, new functions can be incorporated using the developer tool.
Python
Download the folder and run GUI.py. Some required libraries may not be installed.
If you need a .exe version with all the libraries included, please contact the developer.