Skip to content
Open
Show file tree
Hide file tree
Changes from all commits
Commits
File filter

Filter by extension

Filter by extension

Conversations
Failed to load comments.
Loading
Jump to
Jump to file
Failed to load files.
Loading
Diff view
Diff view
1 change: 1 addition & 0 deletions performance/CMakeLists.txt
Original file line number Diff line number Diff line change
Expand Up @@ -4,3 +4,4 @@ function(add_benchmark BENCH_NAME)
endfunction(add_benchmark)

add_benchmark(mutation_benchmark)
add_benchmark(many_short_read_filters)
366 changes: 366 additions & 0 deletions performance/many_short_read_filters.cpp
Original file line number Diff line number Diff line change
@@ -0,0 +1,366 @@
#include <algorithm>
#include <exception>
#include <filesystem>
#include <fstream>
#include <random>
#include <sstream>
#include <stdexcept>

#include <arrow/compute/initialize.h>
#include <spdlog/spdlog.h>

#include "silo/append/database_inserter.h"
#include "silo/append/ndjson_line_reader.h"
#include "silo/initialize/initializer.h"
#include "silo/query_engine/query.h"
#include "silo/storage/reference_genomes.h"

using silo::query_engine::Query;
using silo::Database;

namespace {

constexpr size_t DEFAULT_READ_COUNT = 5'000'000;
constexpr size_t DEFAULT_READ_LENGTH = 200;
constexpr double DEFAULT_MUTATION_RATE = 0.001;
constexpr double DEFAULT_DEATH_RATE = 0.1;
constexpr size_t DEFAULT_GENERATIONS = 5;
constexpr size_t DEFAULT_CHILDREN_PER_NODE = 3;
constexpr size_t DEFAULT_QUERY_COUNT = 10'000;

void changeCwdToTestFolder() {
// Look for the test data directory (`testBaseData`) in the current directory and up to
// <search_depth> directories above the current directory. If found, change the current working
// directory to the directory containing the test data directory
size_t search_depth = 4;
std::filesystem::path candidate_directory = std::filesystem::current_path().string();
for (size_t i = 0; i < search_depth; i++, candidate_directory = candidate_directory / "..") {
if (std::filesystem::exists(candidate_directory / "testBaseData/exampleDataset")) {
std::filesystem::current_path(candidate_directory);
return;
}
}
throw std::runtime_error(fmt::format(
"Should be run in root of repository, got {} and could not find root by heuristics",
std::filesystem::current_path().string()
));
}

std::string readReferenceFromFile() {
auto reference_genomes =
silo::ReferenceGenomes::readFromFile("testBaseData/exampleDataset/reference_genomes.json");
if (reference_genomes.raw_nucleotide_sequences.empty()) {
throw std::runtime_error("No nucleotide sequences found in reference genomes file");
}
return reference_genomes.raw_nucleotide_sequences.at(0);
}

using silo::Nucleotide;

// Simple tree-based sequence evolution model
class SequenceTreeGenerator {
std::mt19937 rng;
const std::string& reference;
double mutation_rate;
double death_rate;
size_t generations;
size_t children_per_node;

char mutateBase(char base) {
std::uniform_int_distribution<size_t> dist(0, 3);
char new_base;
do {
Nucleotide::Symbol new_symbol = Nucleotide::SYMBOLS.at(dist(rng));
new_base = Nucleotide::symbolToChar(new_symbol);
} while (new_base == base);
return new_base;
}

std::string mutateSequence(std::string_view sequence) {
std::string mutated{sequence};
const size_t seq_length = sequence.size();

// Sample the number of mutations from a binomial distribution
std::binomial_distribution<size_t> num_mutations_dist(seq_length, mutation_rate);
size_t num_mutations = num_mutations_dist(rng);

// Randomly choose positions to mutate
std::uniform_int_distribution<size_t> pos_dist(0, seq_length - 1);
for (size_t i = 0; i < num_mutations; ++i) {
size_t pos = pos_dist(rng);
mutated[pos] = mutateBase(mutated[pos]);
}
return mutated;
}

public:
SequenceTreeGenerator(
const std::string& ref,
uint64_t seed = 42,
double mut_rate = DEFAULT_MUTATION_RATE,
double death = DEFAULT_DEATH_RATE,
size_t gens = DEFAULT_GENERATIONS,
size_t children = DEFAULT_CHILDREN_PER_NODE
)
: rng(seed),
reference(ref),
mutation_rate(mut_rate),
death_rate(death),
generations(gens),
children_per_node(children) {}

// Generate evolved sequences using a tree model
std::vector<std::string> generateEvolvedSequences() {
std::vector<std::string> all_generated_sequences = {reference};
std::vector<std::string_view> current_generation = {reference};
std::vector<std::string_view> next_generation;
std::bernoulli_distribution survives(1.0 - death_rate);

for (size_t gen = 0; gen < generations; ++gen) {
next_generation.clear();
for (const auto& seq : current_generation) {
for (size_t child = 0; child < children_per_node; ++child) {
if (survives(rng)) {
all_generated_sequences.push_back(mutateSequence(seq));
next_generation.push_back(all_generated_sequences.back());
}
}
}
if (next_generation.empty()) {
// If all died, keep at least one survivor
next_generation.push_back(all_generated_sequences.back());
}
current_generation = std::move(next_generation);
}
return all_generated_sequences;
}
};

struct ShortRead {
size_t id;
size_t offset;
std::string sequence;
};

// Lazy generator for short reads - generates on-demand without materializing all reads
class ShortReadGenerator {
std::vector<std::string> evolved_sequences;
std::mt19937 rng;
std::uniform_int_distribution<size_t> seq_dist;
size_t count;
size_t read_length;
size_t num_positions;

public:
class iterator {
ShortReadGenerator* generator;
size_t current_id;

public:
using iterator_category = std::input_iterator_tag;
using value_type = ShortRead;
using difference_type = std::ptrdiff_t;
using pointer = const ShortRead*;
using reference = ShortRead;

iterator(ShortReadGenerator* gen, size_t id)
: generator(gen),
current_id(id) {}

ShortRead operator*() { return generator->generateAt(current_id); }

iterator& operator++() {
++current_id;
return *this;
}

iterator operator++(int) {
iterator tmp = *this;
++current_id;
return tmp;
}

bool operator==(const iterator& other) const { return current_id == other.current_id; }
bool operator!=(const iterator& other) const { return current_id != other.current_id; }
};

ShortReadGenerator(
const std::string& reference,
size_t count,
size_t read_length,
uint64_t seed = 42
)
: count(count),
read_length(read_length) {
SequenceTreeGenerator tree_gen(reference, seed);
evolved_sequences = tree_gen.generateEvolvedSequences();

SPDLOG_INFO("Generated {} evolved sequences from tree model", evolved_sequences.size());

const size_t seq_length = reference.size();
SILO_ASSERT(read_length < seq_length);
num_positions = seq_length - read_length + 1;

rng.seed(seed + 1000);
seq_dist = std::uniform_int_distribution<size_t>(0, evolved_sequences.size() - 1);
}

ShortRead generateAt(size_t read_id) {
const size_t offset = (read_id * num_positions) / count;
const auto& source_seq = evolved_sequences[seq_dist(rng)];
return {read_id, offset, source_seq.substr(offset, read_length)};
}

iterator begin() { return iterator(this, 0); }
iterator end() { return iterator(this, count); }

[[nodiscard]] size_t size() const { return count; }
};

std::stringstream generateShortReadNdjson(
const std::string& reference,
size_t count = DEFAULT_READ_COUNT,
size_t read_length = DEFAULT_READ_LENGTH
) {
ShortReadGenerator generator(reference, count, read_length);
std::stringstream buffer;

for (const auto& read : generator) {
buffer << fmt::format(
R"({{"readId":"read_{}","samplingDate":"2024-01-01","locationName":"generated","main":{{"insertions":[],"offset":{},"sequence":"{}"}}}})",
read.id,
read.offset,
read.sequence
) << "\n";
}

return buffer;
}

std::shared_ptr<Database> initializeDatabaseWithSingleReference(std::string reference) {
auto database_config = silo::config::DatabaseConfig::getValidatedConfig(R"(
schema:
instanceName: test
metadata:
- name: readId
type: string
- name: samplingDate
type: date
- name: locationName
type: string
primaryKey: readId
)");

silo::ReferenceGenomes reference_genomes{{{"main", reference}}, {}};

return std::make_shared<silo::Database>(
silo::Database{silo::initialize::Initializer::createSchemaFromConfigFiles(
std::move(database_config),
std::move(reference_genomes),
{},
silo::common::PhyloTree{},
/*without_unaligned_sequences=*/true
)}
);
}

struct TestDatabaseResult {
std::shared_ptr<Database> database;
size_t reference_length;
};

TestDatabaseResult setupTestDatabase() {
std::string reference = readReferenceFromFile();
SPDLOG_INFO("Read reference sequence of length {}", reference.size());
size_t ref_length = reference.size();

auto input_buffer = generateShortReadNdjson(reference);
SPDLOG_INFO("Generated short read NDJSON data");

auto database = initializeDatabaseWithSingleReference(reference);

auto input_data_stream = silo::append::NdjsonLineReader{input_buffer};
silo::append::appendDataToDatabase(*database, input_data_stream);

return {database, ref_length};
}

class QueryGenerator {
std::mt19937 rng;
size_t reference_length;
size_t query_counter = 0;
static constexpr std::array<char, 5> SYMBOLS = {'A', 'C', 'G', 'T', '-'};

public:
QueryGenerator(size_t ref_length, uint64_t seed = 42)
: rng(seed),
reference_length(ref_length) {}

std::string generateQuery() {
std::uniform_int_distribution<size_t> pos_dist(1, reference_length - 1);
size_t position = pos_dist(rng);

bool use_all_symbols = (query_counter++ % 2 == 1);

if (use_all_symbols) {
// Query all 5 symbols (A, C, G, T, -) at the same position in an OR
return fmt::format(
R"({{"action":{{"groupByFields":["samplingDate"],"randomize":false,"type":"Aggregated"}},"filterExpression":{{"children":[{{"children":[{{"children":[{{"column":"locationName","value":"generated","type":"StringEquals"}}],"type":"Or"}},{{"column":"samplingDate","from":"2024-01-01","to":"2024-01-07","type":"DateBetween"}}],"type":"And"}},{{"children":[{{"position":{0},"symbol":"A","type":"NucleotideEquals"}},{{"position":{0},"symbol":"C","type":"NucleotideEquals"}},{{"position":{0},"symbol":"G","type":"NucleotideEquals"}},{{"position":{0},"symbol":"T","type":"NucleotideEquals"}},{{"position":{0},"symbol":"-","type":"NucleotideEquals"}}],"type":"Or"}},{{"column":"samplingDate","from":"2024-01-01","to":"2024-01-07","type":"DateBetween"}}],"type":"And"}}}})",
position
);
}
// Query a single random symbol at the position
std::uniform_int_distribution<size_t> sym_dist(0, SYMBOLS.size() - 1);
char symbol = SYMBOLS[sym_dist(rng)];
return fmt::format(
R"({{"action":{{"groupByFields":["samplingDate"],"randomize":false,"type":"Aggregated"}},"filterExpression":{{"children":[{{"children":[{{"children":[{{"column":"locationName","value":"generated","type":"StringEquals"}}],"type":"Or"}},{{"column":"samplingDate","from":"2024-01-01","to":"2024-01-07","type":"DateBetween"}}],"type":"And"}},{{"position":{},"symbol":"{}","type":"NucleotideEquals"}},{{"column":"samplingDate","from":"2024-01-01","to":"2024-01-07","type":"DateBetween"}}],"type":"And"}}}})",
position,
symbol
);
}
};

void executeAllQueries(
const std::shared_ptr<Database>& database,
size_t reference_length,
size_t query_count = DEFAULT_QUERY_COUNT
) {
QueryGenerator query_gen(reference_length);

for (size_t query_num = 1; query_num <= query_count; ++query_num) {
if (query_num % 1000 == 0) {
SPDLOG_INFO("Executing query number {}", query_num);
}
std::string query_string = query_gen.generateQuery();
auto query = Query::parseQuery(query_string);
auto query_plan = query->toQueryPlan(database, {}, "test_query");
std::ofstream null_output("/dev/null");
query_plan.executeAndWrite(&null_output, /*timeout_in_seconds=*/20);
}
}

void run() {
changeCwdToTestFolder();
SILO_ASSERT(arrow::compute::Initialize().ok());
SPDLOG_INFO("Building database for benchmark:");

auto [database, reference_length] = setupTestDatabase();

SPDLOG_INFO("Starting full query set benchmark ({} queries):", DEFAULT_QUERY_COUNT);
auto start = std::chrono::high_resolution_clock::now();
executeAllQueries(database, reference_length);
auto end = std::chrono::high_resolution_clock::now();
auto duration = std::chrono::duration_cast<std::chrono::milliseconds>(end - start).count();
SPDLOG_INFO("Finished full query set in {}.{:03} seconds", duration / 1000, duration % 1000);
}

} // namespace

int main(){
try {
run();
} catch (std::exception& e) {
SPDLOG_ERROR(e.what());
return EXIT_FAILURE;
}
}
Loading