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MassBank3

MassBank3 is the spectral reference library's next generation software product. The system consists of a modern software architecture and provides a new REST API with different services and a completely redesigned user interface.

A current test instance is running at https://msbi.ipb-halle.de/MassBank/.

Installation

Note

Although this version of MassBank is already considered as fully functional, it is still work in progress and in a testing phase!
Please create a new issue in case of observing any bug or discrepancy.

There are currently two ways to run MassBank:

  1. Docker Compose
  2. Kubernetes/Helm Charts

Docker Compose

Basic Settings

Make sure that Docker and Docker Compose are installed on your computer and ready to use.

Then clone the repository:

git clone https://github.com/MassBank/MassBank3.git

The directory MassBank/compose contains the env.dist file which serves as a template for environment variables. The system expects an .env file in that directory.

So navigate to that directory and copy the env.dist file into a new .env file.

cd MassBank3/compose
cp env.dist .env

Download the latest release of MassBank data in MSP format and move it the data directoy (default):

wget https://github.com/MassBank/MassBank-data/releases/latest/download/MassBank_NIST.msp
mv MassBank_NIST.msp ../data/MassBank_volume/

Now use docker compose to start the system (in daemon mode):

docker compose up -d

Note

Initially, the property MB_DB_INIT is set to true. Change that value to false after the database was filled within the first start. The database filling takes some time. The mb3tool service is responsible for that and stops after finishing that task.

The frontend can (by default) be accessed in the webbrowser at http://localhost:8080/MassBank/.

To stop the system use:

docker compose down -v

Advanced Settings

Google Search Console

This optional feature enables the verification of your MassBank instance by Google search console.

If the .env file contains a non-empty GOOGLE_SEARCH_CONSOLE_KEY property then this key will be used as meta-tag in every HTML document of the web interface.

Distributor's Information

The DISTRIBUTOR_TEXT property is a free text field to insert any description of the distributor of a running MassBank instance.

And DISTRIBUTOR_URL should contain the URL to the distributor's imprint/website.

Troubleshooting

In case your system is different from linux/amd64 then a warning might appear after starting docker compose:

The requested image's platform (linux/amd64) does not match the detected host platform (linux/arm64/v8) and no specific platform was requested

Add the following properties to postgres, similarity-service and export-service in the docker-compose.yaml file to solve that problem:

platform: linux/amd64

Kubernetes/Helm Charts

Description is coming soon.

REST API

There is a graphical interface by means of Swagger UI to have insights into the different API endpoints and their specifications at our test instance.

To access this on your running instance, just visit the API URL in the browser. By default it is http://localhost:8081 and is defined by the environment variable MB3_API_URL.

Examples

/records Endpoint

InChIKey

In order to get all records from the running instance at the API URL with an InChIKey of KWILGNNWGSNMPA-UHFFFAOYSA-N call the following URL:

{MB3_API_URL}/records?inchi_key=KWILGNNWGSNMPA-UHFFFAOYSA-N

The corresponding URL with default value (http://localhost:8081) is:

http://localhost:8081/records?inchi_key=KWILGNNWGSNMPA-UHFFFAOYSA-N

For example, to obtain the results via cURL use:

curl -X GET "http://localhost:8081/records?inchi_key=KWILGNNWGSNMPA-UHFFFAOYSA-N"

The result is a set of complete MassBank records in JSON format.

Compound Name

To receive all records to the compound name mellein use:

http://localhost:8081/records?compound_name=mellein

/records/search Endpoint

Compound Class

To receive all accession belonging to the compound class natural product use:

http://localhost:8081/records/search?compound_class=natural+product

The result is a set of MassBank record IDs (accessions).

MS Type and Ion Mode

A request for searching MS2 spectra and negative ion mode looks like:

http://localhost:8081/records/search?ms_type=MS2&ion_mode=NEGATIVE

Similarity Search

A similarity search request with the semicolon-separated tuples (m/z value, rel. intensity)

133.0648;225
151.0754;94
155.9743;112
161.0597;999
179.0703;750

and threshold value 0.8 looks like:

http://localhost:8081/records/search?peak_list=133.0648%3B225%2C151.0754%3B94%2C155.9743%3B112%2C161.0597%3B999%2C179.0703%3B750&peak_list_threshold=0.8

The result is a set of MassBank record IDs (accessions) and the corresponding similarity score in JSON format. The calculation is done by the matchms package used in our similarity service.