Lead Developer: Kirill Grigorev
Institution: Weill Cornell Medicine
This repository contains the consolidated notebook used in the analysis for:
Al-Turki, T.M., Maranon, D.G., Nelson, C.B., et al.
Telomeric RNA (TERRA) increases in response to spaceflight and high-altitude climbing.
Communications Biology 7, Article number: 698 (2024).
https://doi.org/10.1038/s42003-024-06014-x
This repository hosts a single Jupyter notebook used for the comprehensive analysis of TERRA repeat motifs in RNA-seq data across multiple contexts:
- SpaceX Inspiration4 astronaut blood samples
- NASA Twins Study data
- High-altitude climbing samples (Mt. Everest)
- Simulated microgravity samples
- Ionizing radiation cell culture studies
Key features of the analysis include:
- Telomeric motif detection (
UUAGGG,UUAGG, etc.) via k-mer enrichment - Mann–Whitney U test comparisons across experimental groups
- Pearson correlation analysis of motif co-occurrence
- Visualization of longitudinal expression patterns
202504-I4-TERRA-consolidated_V2.ipynb: Core analysis notebook (Jupyter)202504-I4-TERRA-consolidated.html: Rendered version of the notebook (for quick preview)
If you use this notebook or its derived analysis in your work, please cite the paper above.