Alzheimer's Disease QSP Model (R Implementation)

Madrasi et al. (2021)의 알츠하이머병 QSP 모델을 R로 재현한 프로젝트입니다.

1. Model Validation (Steady State)

[cite_start]67년 시뮬레이션을 통해 약물 투여 전 환자의 Steady State 농도를 검증한 결과입니다.

Species	Compartment	Expected (nM)	Simulated (nM)	Status
Aβ Monomer	Plasma	0.066	0.0663	✅ OK
Aβ Monomer	Brain ISF	0.75	0.731	✅ OK
Aβ Plaque	Brain ISF	39.0	37.4	✅ OK

• [cite_start]Plaque Half-life: 2.75 years (Paper value: ~2.75 years) [cite: 87]
• [cite_start]Aβ plasma t1/2: 1.01 hours (Paper value: ~1 hour) [cite: 87]

2. Methodology

• R Version: 4.x
• Packages: deSolve, ggplot2
• Simulation Time: 67 years (for baseline calibration)