Added Paper (#88)

theislab · Mar 6, 2025 · 687ba3d · 687ba3d
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diff --git a/_data/single-cell-transformers.yml b/_data/single-cell-transformers.yml
@@ -1,3 +1,15 @@
+- model: The Complexity of Automated Cell Type Annotations with GPT-4
+  paper:
+    type: preprint
+    text: '[Soumya Luthra, et al. 2024](https://www.biorxiv.org/content/10.1101/2025.02.11.637659v2)'
+    url: https://www.biorxiv.org/content/10.1101/2025.02.11.637659v2
+  code:
+    type: reproducible
+    text: "[ð\x9F\x9B\_ï¸\x8FGithub](https://github.com/soulbio/cell_type_annotation)"
+    url: https://github.com/soulbio/cell_type_annotation
+
+
+
 - model: BioLLM
   paper:
     type: preprint

diff --git a/_site/_data/single-cell-transformers.yml b/_site/_data/single-cell-transformers.yml
@@ -1,3 +1,66 @@
+- model: The Complexity of Automated Cell Type Annotations with GPT-4
+  paper:
+    type: preprint
+    text: '[Soumya Luthra, et al. 2024](https://www.biorxiv.org/content/10.1101/2025.02.11.637659v2)'
+    url: https://www.biorxiv.org/content/10.1101/2025.02.11.637659v2
+  code:
+    type: reproducible
+    text: "[ð\x9F\x9B\_ï¸\x8FGithub](https://github.com/soulbio/cell_type_annotation)"
+    url: https://github.com/soulbio/cell_type_annotation
+
+
+
+- model: BioLLM
+  paper:
+    type: preprint
+    text: '[Ping Qiu, et al. 2024](https://www.biorxiv.org/content/10.1101/2024.11.22.624786v1.full.pdf)'
+    url: https://www.biorxiv.org/content/10.1101/2024.11.22.624786v1.full.pdf
+  code:
+    type: reproducible
+    text: "[ð\x9F\x9B\_ï¸\x8FGithub](https://github.com/BGIResearch/BioLLM)"
+    url: https://github.com/BGIResearch/BioLLM
+  omic_modalities: '-'
+  pre_training_dataset: '-'
+  input_embedding: '-'
+  architecture: '-'
+  ssl_tasks: '-'
+  supervised_tasks: '-'
+
+
+
+
+- model: scGPT-spatial
+  paper:
+    type: preprint
+    text: '[Chloe Wang, et al. 2024](https://www.biorxiv.org/content/10.1101/2025.02.05.636714v1.full.pdf)'
+    url: https://www.biorxiv.org/content/10.1101/2025.02.05.636714v1.full.pdf
+  code:
+    type: reproducible
+    text: "[ð\x9F\x9B\_ï¸\x8FGithub](https://github.com/bowang-lab/scGPT-spatial)"
+    url: https://github.com/bowang-lab/scGPT-spatial
+  omic_modalities: '-'
+  pre_training_dataset: '-'
+  input_embedding: '-'
+  architecture: '-'
+  ssl_tasks: '-'
+  supervised_tasks: '-'
+
+- model: scCello
+  paper:
+    type: peer_reviewed
+    text: '[Yuan, Xinyu, et al. 2024](https://openreview.net/pdf?id=aeYNVtTo7o)'
+    url: https://openreview.net/pdf?id=aeYNVtTo7o
+  code:
+    type: reproducible
+    text: "[ð\x9F\x9B\_ï¸\x8FGithub](https://github.com/DeepGraphLearning/scCello)"
+    url: https://github.com/DeepGraphLearning/scCello
+  omic_modalities: scRNA-seq
+  pre_training_dataset: 23M / cross-tissue, human ([CELLxGENE](https://cellxgene.cziscience.com/))
+  input_embedding: 'Ordering: rank-based'
+  architecture: Encoder
+  ssl_tasks: 'Multi-level pre-training: MLM with CE loss for gene level modeling; an ontologybased cell-type coherence loss for intra-cellular level modeling; a relational alignment loss to inject cell-type lineage from cell ontology graph for inter-cellular level modeling'
+  supervised_tasks: 'fine-tuning tasks: cell type classification; zero-shot tasks: cell type annotation, marker gene prediction, novel cell type prediction, cancer drug prediction'
+
 - model: scGREAT
   paper:
     type: peer_reviewed
@@ -14,6 +77,22 @@
   ssl_tasks: '-'
   supervised_tasks: '-'
 
+- model: MAMMAL
+  paper:
+    type: preprint
+    text: '[Shoshan et al. 2024](https://arxiv.org/abs/2410.22367)'
+    url: https://arxiv.org/abs/2410.22367
+  code:
+    type: reproducible
+    text: "[ð\x9F\x9B\_ï¸\x8FGitHub](https://github.com/BiomedSciAI/biomed-multi-alignment)"
+    url: https://github.com/BiomedSciAI/biomed-multi-alignment
+  omic_modalities: bulk/scRNA-seq, amino acid sequences, SMILES molecule sequences
+  pre_training_dataset: CellXGene Human
+  input_embedding: '-'
+  architecture: T5 Encoder-Decoder
+  ssl_tasks: Expression-ranked gene masking (CELLxGENE Human), Protein LM (Uniref90), Antibody LM (OAS), Antibody Denoising (OAS), Small-Molecule LM (ZINC), Protein Interaction LM (STRING)
+  supervised_tasks: Cell type annotation (zheng68k), Cancer drug response prediction (GDSC1/2/3), Brain Blood Barrier Penetration prediction (MoleculeNet), Small-Molecule toxicity prediction (MoleculeNet), drug clinical trial result prediction (MoleculeNet), Antibody-Antigen binding prediction (HER2), Targeted antibody generation (SAbDAb), Protein-Protein delta-delta G  prediction (SKEMPI v2), Drug-Target interaction prediction (PEER), TCR binding prediction (Weber et al)  
+
 - model: Nicheformer
   paper:
     type: peer_reviewed
@@ -145,22 +224,6 @@
   supervised_tasks: '-'
 
 
-- model: scCello
-  paper:
-    type: preprint
-    text: '[Xinyu Yuan et al. 2024](https://github.com/theislab/single-cell-transformer-papers/issues/32)'
-    url: https://github.com/theislab/single-cell-transformer-papers/issues/32
-  code:
-    type: '-'
-    text: "[ð\x9F\x94\x8DGitHub](https://github.com/DeepGraphLearning/scCello)"
-    url: 'https://github.com/DeepGraphLearning/scCello'
-  omic_modalities: '-'
-  pre_training_dataset: '-'
-  input_embedding: '-'
-  architecture: '-'
-  ssl_tasks: '-'
-  supervised_tasks: '-'
-
 - model: scGenePT
   paper:
     type: preprint

diff --git a/_site/_data/transformer-evaluation.yml b/_site/_data/transformer-evaluation.yml
@@ -26,22 +26,6 @@
   tasks: '-'
   notes: '-'
 
-
-- paper:
-    type: preprint
-    text: '[George Crowley et al. 2024](https://www.biorxiv.org/content/10.1101/2024.10.10.617605v1.full.pdf)'
-    url: https://www.biorxiv.org/content/10.1101/2024.10.10.617605v1.full.pdf
-  code:
-    type: 'reproducible'
-    text: '[ð\x9F\x9B\_ï¸\x8FGitHub](https://github.com/ggit12/anndictionary/)'
-    url: 'https://github.com/ggit12/anndictionary/'
-  omic_modalities: '-'
-  evaluated_transformers: '-'
-  tasks: '-'
-  notes: '-'
-
-
-
 - paper:
     type: preprint
     text: '[George Crowley et al. 2024](https://www.biorxiv.org/content/10.1101/2024.10.10.617605v1.full.pdf)'
@@ -77,10 +61,10 @@
     type: 'reproducible'
     text: '[ð\x9F\x9B\_ï¸\x8FGitHub](https://github.com/aaronwtr/PertEval)'
     url: 'https://github.com/aaronwtr/PertEval'
-  omic_modalities: '-'
-  evaluated_transformers: '-'
-  tasks: '-'
-  notes: '-'
+  omic_modalities: 'scRNA-seq'
+  evaluated_transformers: 'UCE, scBERT, scGPT, Geneformer, scFoundation'
+  tasks: 'Transcriptomic perturbation prediction'
+  notes: 'Introduces PertEval-scFM, a benchmark to assess the zero-shot utility of single-cell foundation model embeddings for transcriptomic perturbation prediction. Uses SPECTRA to generate train-test splits with increasing dissimilarity to evaluate robustness against distribution shift. Models are evaluated with MSE and AUSPC, with AUSPC reflecting robustness under distribution shift. Additional analyses include E-distance and predicted transcriptomic distributions across the top 20 DEGs. Findings suggest that single-cell foundation model embeddings capture average perturbation effects but generally lack robustness to distribution shift. Ongoing work demonstrates that the domain-specific model GEARS outperforms foundation model embeddings, indicating that masked-language modeling on gene expression data without domain-specific inductive biases is insufficient for accurate transcriptomic perturbation prediction.'
 
 
 
@@ -194,3 +178,15 @@
   evaluated_transformers: scGPT, Geneformer, scBERT
   tasks: Cell type annotation
   notes: Focused on imbalanced cell type classification. Geneformer appears to be outperformed by scGPT and scBERT, where the two latter perform similarly.
+- paper:
+    type: preprint
+    text: '[Csendes et al. 2024](https://www.biorxiv.org/content/10.1101/2024.09.30.615843v1)'
+    url: https://www.biorxiv.org/content/10.1101/2024.09.30.615843v1
+  code:
+    type: reproducible
+    text: "[ð\x9F\x9B\_ï¸\x8FGitHub](https://github.com/turbine-ai/PerturbSeqPredBenchmark)"
+    url: https://github.com/turbine-ai/PerturbSeqPredBenchmark
+  omic_modalities: scRNA-seq
+  evaluated_transformers: scGPT
+  tasks: Genetic perturbation effect prediction
+  notes: Simple baseline models can outperform scGPT on perturbational downstream tasks. The most widely used benchmarking datasets contain significant biases, making them suboptimal for evaluation.
diff --git a/_site/_pages/implementations.html b/_site/_pages/implementations.html
diff --git a/_site/feed.xml b/_site/feed.xml
@@ -1 +1 @@
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diff --git a/_site/implementations.html b/_site/implementations.html
diff --git a/_site/index.html b/_site/index.html
diff --git a/_site/single-cell-transformers.html b/_site/single-cell-transformers.html
diff --git a/_site/transformer-evaluation.html b/_site/transformer-evaluation.html
diff --git a/_site/transformer-llms.html b/_site/transformer-llms.html
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